Journal article
Characterizing Alterations in Executive Functioning Across Distinct Subtypes of Cortical and Subcortical Dementia
Clinical neuropsychologist, v 18(1), pp 22-31
01 Feb 2004
PMID: 15595355
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Differential patterns of executive function deficits (EFD) exist in cortical and subcortical dementia; however, little work exists attempting to integrate these findings into a conceptual framework. The current study aimed to characterize EFD in cortical and subcortical dementia. Patients with Alzheimer's disease (AD; n=65), subcortical ischemic vascular dementia (IVD; n=64), or Parkinson's disease with dementia (dPD; n=21) completed a variety of measures purported to require executive systems. We extracted variables of interest from measures shown in a growing body of literature to be associated with EFD in dementia. These measures included the Boston Revision of the WMS Mental Control subtest, letter fluency, WAIS-R Similarities subtest, CVLT, the Graphical Sequence Test-Dementia version, and Clock Drawing. When submitted to a PCA with varimax rotation, these variables produced a four-component solution (62% of the variance). Component 1 appeared to reflect adequacy of working memory, Component 2 irrelevant or context non-specific interference, Component 3 reflected response preparation and Component 4 relevant or context-specific interference. Post hoc analyses of z-transformed composite scores revealed that AD differentially affected context-specific interference, IVD and dPD disrupted working memory and response preparation while IVD differentially affected context non-specific interference. EFD in dementia can be divided into specific components that are differentially impaired by cortical and subcortical dementias. Implications for an overall conceptual framework of EFD in dementia are discussed.
Metrics
Details
- Title
- Characterizing Alterations in Executive Functioning Across Distinct Subtypes of Cortical and Subcortical Dementia
- Creators
- Melissa Lamar - National Institute on AgingRod Swenson - University of North DakotaEdith Kaplan - Suffolk UniversityDavid J. Libon - Rowan University
- Publication Details
- Clinical neuropsychologist, v 18(1), pp 22-31
- Publisher
- Taylor & Francis Group
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000223602500004
- Scopus ID
- 2-s2.0-4444333674
- Other Identifier
- 991021901314204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Psychology
- Psychology, Clinical