Journal article
Characterizing the Immune Environment in Peritoneal Carcinomatosis: Insights for Novel Immunotherapy Strategies
Annals of surgical oncology, v 31(3), pp 2069-2077
Mar 2024
PMID: 37996643
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Carcinomatosis, a distinct pattern of metastatic cancer in the peritoneal cavity, poses challenges for treatment and has limited therapeutic options. Understanding the immune environment of peritoneal surface malignancies is crucial for developing effective immunotherapeutic approaches. This study characterizes soluble immune mediators in the peritoneal fluid of patients with and without carcinomatosis to identify targets for novel treatment strategies.
Serum and peritoneal fluid samples were collected from surgical patients, and a multianalyte analysis was performed using the Luminex platform. Patient characteristics, tumor sites, and sample collection details were recorded. Soluble immune mediator levels were measured and compared between peritoneal fluid and serum samples and among clinical subgroups. Statistical analysis was conducted to assess differences in analyte concentrations and correlations between samples.
There were 39 patients included in the study, with varying surgical indications. Significant differences were observed in soluble immune mediator levels between peritoneal fluid and serum, with peritoneal fluid exhibiting lower concentrations. Carcinomatosis was associated with elevated levels of proinflammatory mediators, including IL-6 and IL-8, while adaptive immune response markers were low in peritoneal fluid.
The peritoneal immune microenvironment in carcinomatosis favors innate immunity, presenting a challenging environment for effective antitumor response. High levels of proinflammatory mediators suggest potential targets for intervention, such as the IL-6 axis, FGF2, IL-8, and CCL2; these could be explored as potential mitigators of malignant ascites and enhance anti-tumor immune responses. These findings provide valuable insights for developing immunotherapy strategies and improving outcomes in patients with peritoneal carcinomatosis.
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Details
- Title
- Characterizing the Immune Environment in Peritoneal Carcinomatosis: Insights for Novel Immunotherapy Strategies
- Creators
- Patrick L Wagner - Allegheny Health NetworkChelsea M Knotts - Allegheny Health NetworkVera S Donneberg - University of PittsburghNeda Dadgar - Cleveland Eye ClinicChristian X Cruz Pico - Allegheny Health NetworkKunhong Xiao - Allegheny Health NetworkAli Zaidi - Allegheny Health NetworkSuzanne C Schiffman - Allegheny Health NetworkCasey J Allen - Allegheny Health NetworkAlbert D Donnenberg - Drexel University, General Internal MedicineDavid L Bartlett - Allegheny Health Network
- Publication Details
- Annals of surgical oncology, v 31(3), pp 2069-2077
- Number of pages
- 9
- Grant note
- P30CA047904 / Cancer Center Support Grant W81XWH2210009_BC210533 / U.S. Department of Defense FP00002718 / METAvivor W81XWH2211069_ BC211396 / U.S. Department of Defense
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Surgery; General Internal Medicine
- Web of Science ID
- WOS:001123376300003
- Scopus ID
- 2-s2.0-85175062532
- Other Identifier
- 991021861314804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Surgery