Journal article
Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements
PloS one, v 19(7), 0305254
25 Jul 2024
PMID: 39052686
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Advanced optical neuromonitoring of cerebral hemodynamics with hybrid diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) methods holds promise for non-invasive characterization of brain health in critically ill patients. However, the methods' fiber-coupled patient interfaces (probes) are challenging to apply in emergent clinical scenarios that require rapid and reproducible attachment to the head. To address this challenge, we developed a novel chassis-based optical probe design for DOS/DCS measurements and validated its measurement accuracy and reproducibility against conventional, manually held measurements of cerebral hemodynamics in pediatric swine (n = 20). The chassis-based probe design comprises a detachable fiber housing which snaps into a 3D-printed, circumferential chassis piece that is secured to the skin. To validate its reproducibility, eight measurement repetitions of cerebral tissue blood flow index (BFI), oxygen saturation (StO2), and oxy-, deoxy- and total hemoglobin concentration were acquired at the same demarcated measurement location for each pig. The probe was detached after each measurement. Of the eight measurements, four were acquired by placing the probe into a secured chassis, and four were visually aligned and manually held. We compared the absolute value and intra-subject coefficient of variation (CV) of chassis versus manual measurements. No significant differences were observed in either absolute value or CV between chassis and manual measurements (p > 0.05). However, the CV for BFI (mean ± SD: manual, 19.5% ± 9.6; chassis, 19.0% ± 10.8) was significantly higher than StO2 (manual, 5.8% ± 6.7; chassis, 6.6% ± 7.1) regardless of measurement methodology (p<0.001). The chassis-based DOS/DCS probe design facilitated rapid probe attachment/re-attachment and demonstrated comparable accuracy and reproducibility to conventional, manual alignment. In the future, this design may be adapted for clinical applications to allow for non-invasive monitoring of cerebral health during pediatric critical care.
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Details
- Title
- Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements
- Creators
- Giselle C Matlis - Drexel University, School of Biomedical Engineering, Science, and Health SystemsQihuang Zhang - McGill UniversityEmilie J Benson - University of PennsylvaniaM Katie Weeks - Children's Hospital of PhiladelphiaKristen Andersen - Children's Hospital of PhiladelphiaJharna Jahnavi - Children's Hospital of PhiladelphiaAlec Lafontant - Children's Hospital of PhiladelphiaJake Breimann - Children's Hospital of PhiladelphiaThomas Hallowell - Children's Hospital of PhiladelphiaYuxi Lin - Children's Hospital of PhiladelphiaDaniel J Licht - Children's Hospital of PhiladelphiaArjun G Yodh - University of PennsylvaniaTodd J Kilbaugh - Children's Hospital of PhiladelphiaRodrigo M Forti - Children's Hospital of PhiladelphiaBrian R White - Children's Hospital of PhiladelphiaWesley B Baker - University of PennsylvaniaRui Xiao - University of PennsylvaniaTiffany S Ko - Children's Hospital of Philadelphia
- Publication Details
- PloS one, v 19(7), 0305254
- Publisher
- PLOS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001277540300012
- Scopus ID
- 2-s2.0-85199630161
- Other Identifier
- 991021906507404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Optics