In continuation of our previous reports on the broad-spectrum antimicrobial activity of atmospheric non-thermal dielectric barrier discharge (DBD) plasma treated N-Acetylcysteine (NAC) solution against planktonic and biofilm forms of different multidrug resistant microorganisms, we present here the chemical changes that mediate inactivation of Escherichia coli. In this study, the mechanism and products of the chemical reactions in plasma-treated NAC solution are shown. UV-visible spectrometry, FT-IR, NMR, and colorimetric assays were utilized for chemical characterization of plasma treated NAC solution. The characterization results were correlated with the antimicrobial assays using determined chemical species in solution in order to confirm the major species that are responsible for antimicrobial inactivation. Our results have revealed that plasma treatment of NAC solution creates predominantly reactive nitrogen species versus reactive oxygen species, and the generated peroxynitrite is responsible for significant bacterial inactivation.
Chemical Changes in Nonthermal Plasma-Treated N-Acetylcysteine (NAC) Solution and Their Contribution to Bacterial Inactivation
Creators
Utku K. Ercan - Drexel University
Josh Smith - Drexel University
Hai-Feng Ji - Drexel University
Ari D. Brooks - Hospital of the University of Pennsylvania
Suresh G. Joshi - Drexel University
Publication Details
Scientific reports, Vol.6, pp.20365-20365
Publisher
Springer Nature
Number of pages
13
Grant note
Ministry of National Education, Government of Turkey; Ministry of National Education - Turkey
Department of Surgery, Drexel University College of Medicine
Resource Type
Journal article
Language
English
Academic Unit
School of Biomedical Engineering, Science, and Health Systems; Chemistry
Identifiers
991019167674404721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Physics, Fluids & Plasmas
Research Home Page
Browse by research and academic units
Learn about the ETD submission process at Drexel
Learn about the Libraries’ research data management services