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Journal article
Chemical Changes in Nonthermal Plasma-Treated N-Acetylcysteine (NAC) Solution and Their Contribution to Bacterial Inactivation
Scientific reports, Vol.6, pp.20365-20365
02 Feb 2016
PMCID: PMC4735827
PMID: 26832829
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In continuation of our previous reports on the broad-spectrum antimicrobial activity of atmospheric non-thermal dielectric barrier discharge (DBD) plasma treated N-Acetylcysteine (NAC) solution against planktonic and biofilm forms of different multidrug resistant microorganisms, we present here the chemical changes that mediate inactivation of Escherichia coli. In this study, the mechanism and products of the chemical reactions in plasma-treated NAC solution are shown. UV-visible spectrometry, FT-IR, NMR, and colorimetric assays were utilized for chemical characterization of plasma treated NAC solution. The characterization results were correlated with the antimicrobial assays using determined chemical species in solution in order to confirm the major species that are responsible for antimicrobial inactivation. Our results have revealed that plasma treatment of NAC solution creates predominantly reactive nitrogen species versus reactive oxygen species, and the generated peroxynitrite is responsible for significant bacterial inactivation.
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Details
- Title
- Chemical Changes in Nonthermal Plasma-Treated N-Acetylcysteine (NAC) Solution and Their Contribution to Bacterial Inactivation
- Creators
- Utku K. Ercan - Drexel UniversityJosh Smith - Drexel UniversityHai-Feng Ji - Drexel UniversityAri D. Brooks - Hospital of the University of PennsylvaniaSuresh G. Joshi - Drexel University
- Publication Details
- Scientific reports, Vol.6, pp.20365-20365
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- Ministry of National Education, Government of Turkey; Ministry of National Education - Turkey Department of Surgery, Drexel University College of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Chemistry
- Identifiers
- 991019167674404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physics, Fluids & Plasmas