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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Chemical approaches to understanding O-GlcNAc glycosylation in the brain
Nature chemical biology, v 4(2), pp 97-106
01 Feb 2008
PMID: 18202679
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
O-GlcNAc glycosylation is a unique, dynamic form of glycosylation found on intracellular proteins of all multicellular organisms. Studies suggest that O-GlcNAc represents a key regulatory modification in the brain, contributing to transcriptional regulation, neuronal communication and neurodegenerative disease. Recently, several new chemical tools have been developed to detect and study the modification, including chemoenzymatic tagging methods, quantitative proteomics strategies and small-molecule inhibitors of O-GlcNAc enzymes. Here we highlight some of the emerging roles for O-GlcNAc in the nervous system and describe how chemical tools have significantly advanced our understanding of the scope, functional significance and cellular dynamics of this modification.
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Details
- Title
- Chemical approaches to understanding O-GlcNAc glycosylation in the brain
- Creators
- Jessica E. Rexach - California Institute of TechnologyPeter M. Clark - Howard Hughes Medical InstituteLinda C. Hsieh-Wilson - Howard Hughes Medical Institute
- Publication Details
- Nature chemical biology, v 4(2), pp 97-106
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- F31 NS056525-02; F31 NS056525 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01GM084724 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) F31NS056525 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01 GM084724-05; R01 GM084724 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000252585400007
- Scopus ID
- 2-s2.0-38349064791
- Other Identifier
- 991019356498004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology