Journal article
Chemotherapy-mediated lncRNA-induced immune cell plasticity in cancer immunopathogenesis
International immunopharmacology, v 141, 112967
15 Nov 2024
PMID: 39181018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•LncRNAs are essential regulators of the immune system and plasticity.•lncRNAs affect immune cells, modifying the tumor’s surrounding immune environment.•LncRNAs can generate either immunosuppressive or immune-enhancer microenvironments.•Targeting lncRNAs helps advance malignancies and overcome drug resistance to cancer.
Tumor cells engage with the immune system in a complex manner, utilizing evasion and adaptability mechanisms. The development of cancer and resistance to treatment relies on the ability of immune cells to adjust their phenotype and function in response to cues from the tumor microenvironment, known as immunological cell plasticity. This study delves into the role of long non-coding RNAs (lncRNAs) in enhancing immune cell flexibility in cancer, focusing on their regulatory actions in the tumor microenvironment and potential therapeutic implications. Through a comprehensive review of existing literature, the study analyzes the impact of lncRNAs on macrophages, T-cells, and MDSCs, as well as the influence of cytokines and growth factors like TNF, IL-6, HGF, and TGFβ on immunological cell plasticity and tumor immunoediting. LncRNAs exert a strong influence on immune cell plasticity through mechanisms such as transcriptional regulation, post-transcriptional modifications, and chromatin remodeling. These RNA molecules intricately modulate gene expression networks, acting as scaffolding, decoys, guides, and sponges. Moreover, both direct cell–cell interactions and soluble chemicals in the tumor microenvironment contribute to enhancing immune cell activation and survival. Understanding the influence of lncRNAs on immune cell flexibility sheds light on the biological pathways of immune evasion and cancer progression. Targeting long non-coding RNAs holds promise for amplifying anti-tumor immunity and overcoming drug resistance in cancer treatment. However, further research is necessary to determine the therapeutic potential of manipulating lncRNAs in the tumor microenvironment.
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Details
- Title
- Chemotherapy-mediated lncRNA-induced immune cell plasticity in cancer immunopathogenesis
- Creators
- Jingyuan Lu - Huazhong University of Science and TechnologyHaowei Ma - Case Western Reserve UniversityQian Wang - University Hospitals of ClevelandZhiheng Song - Drexel UniversityJinli Wang - Georgetown University
- Publication Details
- International immunopharmacology, v 141, 112967
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- C. and J. Nyheim Plasma Institute
- Web of Science ID
- WOS:001301548800001
- Scopus ID
- 2-s2.0-85201749034
- Other Identifier
- 991022202120604721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Pharmacology & Pharmacy