Journal article
Childhood Depression: Pharmacological Therapy/Treatment (Pharmacotherapy of Childhood Depression)
Journal of clinical child and adolescent psychology, v 30(1), pp 88-97
01 Feb 2001
PMID: 11294082
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Critiqued the published double-blind, placebo-controlled studies of antidepressant pharmacotherapy in child and adolescent major depressive disorder to assess their overall efficacy. The pharmacological mechanism of antidepressant action also was discussed. At best, antidepressant treatment for depressed youths is only modestly effective. In particular, the tricyclic antidepressants are not superior to placebo; however, early evidence with the selective serotonin reuptake inhibitors is more encouraging. The theoretical basis for this response pattern is discussed from a methodological perspective, from a neurodevelopmental status, and from a biological viewpoint. Study modifications are suggested which could improve some of the methodological limitations apparent in previous clinical drug trials.
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Details
- Title
- Childhood Depression: Pharmacological Therapy/Treatment (Pharmacotherapy of Childhood Depression)
- Creators
- Karen Dineen Wagner - The University of Texas Medical Branch at GalvestonPaul J. Ambrosini - Drexel University
- Publication Details
- Journal of clinical child and adolescent psychology, v 30(1), pp 88-97
- Publisher
- Lawrence Erlbaum Associates, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000167895400009
- Scopus ID
- 2-s2.0-0035288143
- Other Identifier
- 991019167822404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychology, Clinical
- Psychology, Developmental