Journal article
Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies
The Lancet (British edition), v 356(9248), pp 2155-2156
23 Dec 2000
PMID: 11191545
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We identified maternal microchimerism by fluorescence in-situ hybridisation in magnetically-separated CD4 or CD8 peripheral blood cells of eight of nine male patients with juvenile idiopathic inflammatory myopathy, compared with two of nine healthy male controls. We also found maternal microchimerism in inflammatory lesions (one skin sample and nine muscle biopsy samples) of all ten patients examined, compared with two of ten biopsy samples from patients with other muscle disorders. These results suggest that maternal cells may be involved in the pathogenesis of juvenile idiopathic inflammatory myopathy.
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Details
- Title
- Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies
- Creators
- Carol M Artlett - Thomas Jefferson UniversityRon Ramos - Thomas Jefferson UniversitySergAio A Jiminez - Thomas Jefferson UniversityKathleen Patterson - Seattle Children's HospitalFrederick W Miller - National Institute of Arthritis and Musculoskeletal and Skin DiseasesLisa G Rider - National Institute of Arthritis and Musculoskeletal and Skin Diseasesfor the Childhood Myositis Heterogeneity Collaborative
- Publication Details
- The Lancet (British edition), v 356(9248), pp 2155-2156
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000165997300016
- Scopus ID
- 2-s2.0-0034509431
- Other Identifier
- 991020202346004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, General & Internal