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Chlamydia muridarum major outer membrane protein-specific antibodies inhibit in vitro infection but enhance pathology in vivo
Journal article   Open access   Peer reviewed

Chlamydia muridarum major outer membrane protein-specific antibodies inhibit in vitro infection but enhance pathology in vivo

Kelly A Cunningham, Alison J Carey, Louise Hafner, Peter Timms and Kenneth W Beagley
American journal of reproductive immunology (1989), v 65(2), pp 118-126
Feb 2011
DOI: https://doi.org/10.1111/j.1600-0897.2010.00894.x
PMID: 20618179
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1111/j.1600-0897.2010.00894.xView
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Adjuvants, Immunologic Animals Antibodies, Bacterial - administration & dosage Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibody Specificity Bacterial Outer Membrane Proteins - administration & dosage Bacterial Outer Membrane Proteins - immunology Chlamydia Infections - immunology Chlamydia Infections - microbiology Chlamydia Infections - physiopathology Chlamydia muridarum - immunology Chlamydia muridarum - pathogenicity Cholera Toxin - administration & dosage Cholera Toxin - immunology CpG Islands Disease Models, Animal Female Humans Immunization Mice Mice, Inbred BALB C Neutralization Tests Vagina - immunology
Chlamydia trachomatis is a significant worldwide health problem, and the often-asymptomatic disease can result in infertility. To develop a successful vaccine, a complete understanding of the immune response to chlamydial infection and development of genital tract pathology is required. We utilized the murine genital model of chlamydial infection. Mice were immunized with chlamydial major outer membrane protein, and vaginal lavage was assessed for the presence of neutralizing antibodies. These samples were then pre-incubated with Chlamydia muridarum and administered to the vaginal vaults of immune-competent female BALB/c mice to determine the effect on infection. The administration of C. muridarum in conjunction with neutralizing antibodies reduced the numbers of mice infected, but a surprising finding was that this accelerated the development of severe oviduct pathology. Antibodies play an under-recognized role in chlamydial infection and pathology development, which possibly involves interaction with Th1 immunity.

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9 citations in Web of Science
11 citations in Scopus

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Web of Science research areas
Immunology
Reproductive Biology
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