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Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors
Journal article   Peer reviewed

Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors

B. Poeschla, J. Gibbs, K. J. Simansky, D. Greenberg and G. P. Smith
American journal of physiology. Regulatory, integrative and comparative physiology, v 264(1), pp R62-R64
01 Jan 1993
DOI: https://doi.org/10.1152/ajpregu.1993.264.1.R62
PMID: 8430887
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

To investigate the dependence of the satiating action of cholecystokinin on serotonergic function in rats, we examined the effects of systemic pretreatment with serotonin (5-HT) antagonists of varying selectivity for 5-HT receptor subtypes on suppression of food intake induced by systemic administration of cholecystokinin octapeptide (CCK-8). Mianserin, a 5-HT1C/2-selective antagonist, significantly attenuated the satiating action of CCK-8. Ketanserin, a 5-HT2 antagonist, and three 5-HT3 antagonists, MDL-72222, ICS 205-930, and ondansetron, however, had no effect on the satiating action of CCK-8. These results demonstrate that the satiating action of exogenous CCK depends on activation of 5-HT1 (probably 5-HT1C) receptors and that activation of 5-HT2 or 5-HT3 receptors is not required.

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48 citations in Web of Science
56 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Physiology
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