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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Cholinergic regulation of the posterior medial thalamic nucleus
Journal of neurophysiology, v 96(5), pp 2265-2273
01 Nov 2006
PMID: 16870838
Abstract
We previously showed that the GABAergic nucleus zona incerta (ZI) suppresses vibrissae-evoked responses in the posterior medial (POm) thalamus of the rodent somatosensory system. We proposed that this inhibitory incertothalamic pathway regulates POm responses during different behavioral states. Here we tested the hypothesis that this pathway is modulated by the ascending brain stem cholinergic system, which regulates sleep-wake cycles and states of vigilance. We demonstrate that cholinergic inputs facilitate POm responses to vibrissae stimulation. Activation of the cholinergic system by stimulation of brain stem cholinergic nuclei (laterodorsal tegmental and the pedunculopontine tegmental) or by tail pinch significantly increased the magnitude of POm responses to vibrissae stimulation. Microiontophoresis of the muscarinic receptor agonist carbachol enhanced POm responses to vibrissae stimulation. Application of carbachol to an in vitro slice preparation reduced the frequency but not the amplitude of miniature inhibitory postsynaptic currents, indicating a presynaptic site of action for carbachol. We conclude that the cholinergic system facilitates POm responses by suppressing GABAergic inputs from ZI. We propose the state-dependent gating hypothesis, which asserts that differing behavioral states, regulated by the brain stem cholinergic system, modulate the flow of information through POm.
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Details
- Title
- Cholinergic regulation of the posterior medial thalamic nucleus
- Creators
- Radi Masri - University of Maryland, BaltimoreJason C TrageserTatiana BezdudnayaYing LiAsaf Keller
- Publication Details
- Journal of neurophysiology, v 96(5), pp 2265-2273
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000241328900011
- Scopus ID
- 2-s2.0-33751204428
- Other Identifier
- 991021899209404721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Physiology