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Journal article
Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort
American journal of ophthalmology, v 160(1), pp 62-71.e2
01 Jul 2015
PMID: 25896460
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To examine the relationship of choroidal thickness with axial length (AL) and myopia in young adult eyes in the ethnically diverse Correction of Myopia Evaluation Trial (COMET) cohort.
Cross-sectional, multicenter study.
In addition to measures of myopia by cycloplegic autorefraction and AL by A-scan ultrasonography, participants underwent optical coherence tomography imaging of the choroid in both eyes at their last visit (14 years after baseline). Using digital calipers, 2 independent readers measured choroidal thickness in the right eye (left eye if poor quality; n = 37) at 7 locations: fovea and 750, 1500, and 2250 μm nasal (N) and temporal (T) to the fovea.
Choroidal thickness measurements were available from 294 of 346 (85%) imaged participants (mean age: 24.3 ± 1.4 years; 44.9% male) with mean myopia of -5.3 ± 2.0 diopters and mean AL of 25.5 ± 1.0 mm. Overall, choroidal thickness varied by location (P < .0001) and was thickest at the fovea (273.8 ± 70.9 μm) and thinnest nasally (N2250, 191.5 ± 69.3 μm). Multivariable analyses showed significantly thinner choroids in eyes with more myopia and longer AL at all locations except T2250 (P ≤ .001) and presence of peripapillary crescent at all locations except T1500 and T2250 (P ≤ .0001). Choroidal thickness varied by ethnicity at N2250 (P < .0001), with Asians having the thinnest and African Americans the thickest choroids.
Choroids are thinner in longer, more myopic young adult eyes. The thinning was most prominent nasally and in eyes with a crescent. In the furthest nasal location, ethnicity was associated with choroidal thickness. The findings suggest that choroidal thickness should be evaluated, especially in the nasal regions where myopic degenerations are most commonly seen clinically.
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- Title
- Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort
- Creators
- Elise Harb - New England College of OptometryLeslie Hyman - Stony Brook UniversityJane Gwiazda - New England College of OptometryWendy Marsh-Tootle - University of Alabama at BirminghamQinghua Zhang - Stony Brook UniversityWei Hou - Stony Brook UniversityThomas T Norton - University of Alabama at BirminghamKatherine Weise - University of Alabama at BirminghamKeri Dirkes - University of California San DiegoLinda M Zangwill - University of California San DiegoCOMET Study GroupMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- American journal of ophthalmology, v 160(1), pp 62-71.e2
- Publisher
- Elsevier
- Grant note
- U10 EY011752 / NEI NIH HHS EY11754 / NEI NIH HHS EY11752 / NEI NIH HHS P30 EY007551 / NEI NIH HHS P30EY022589 / NEI NIH HHS EY11756 / NEI NIH HHS U10 EY011755 / NEI NIH HHS U10 EY011740 / NEI NIH HHS P30 EY022589 / NEI NIH HHS EY11740 / NEI NIH HHS EY11755 / NEI NIH HHS EY11805 / NEI NIH HHS U10 EY011756 / NEI NIH HHS EY023263 / NEI NIH HHS U10 EY011754 / NEI NIH HHS U10 EY011805 / NEI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000356908600009
- Scopus ID
- 2-s2.0-84930938788
- Other Identifier
- 991021900196604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology