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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Chromatin dynamics associated with HIV-1 Tat-activated transcription
Biochimica et biophysica acta. Gene regulatory mechanisms, v 1799(3), pp 275-285
01 Mar 2010
PMID: 19716452
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chromatin remodeling is an essential event for HIV-1 transcription. Over the last two decades this field of research has come to the forefront, as silencing of the HIV-1 provirus through chromatin modifications has been linked to latency. Here, we focus on chromatin remodeling, especially in relation to the transactivator Tat, and review the most important and newly emerging studies that investigate remodeling mechanisms. We begin by discussing covalent modifications that can alter chromatin structure including acetylation, deacetylation, and methylation, as well as topics addressing the interplay between chromatin remodeling and splicing. Next, we focus on complexes that use the energy of ATP to remove or secure nucleosomes and can additionally act to control HIV-1 transcription. Finally, we cover recent literature on viral microRNAs which have been shown to alter chromatin structure by inducing methylation or even by remodeling nucleosomes.
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Details
- Title
- Chromatin dynamics associated with HIV-1 Tat-activated transcription
- Creators
- Rebecca Easley - George Washington UniversityRachel Van Duyne - Washington University Medical CenterWill Coley - George Washington UniversityIrene Guendel - Washington University Medical CenterSherry Dadgar - Washington University Medical CenterKylene Kehn-Hall - George Washington UniversityFatah Kashanchi - J. Craig Venter Institute
- Publication Details
- Biochimica et biophysica acta. Gene regulatory mechanisms, v 1799(3), pp 275-285
- Publisher
- Elsevier
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000276320800013
- Scopus ID
- 2-s2.0-77949264838
- Other Identifier
- 991021902520504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics