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Journal article
Chronic Low Dose Morphine Does Not Alter Two In Vitro BBB Models
Brain sciences, v 12(7), p888
01 Jan 2022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The blood–brain barrier (BBB) mediates cellular and molecular passage between the central nervous system (CNS) and peripheral circulation. Compromised BBB integrity has been linked to neurocognitive deficits in multiple diseases and various infections, including those associated with HIV-1 infection. Understanding the impact of exposure to pharmaceuticals, such as those utilized for pain management by patients suffering from CNS disease, on BBB regulation and function is clinically important. In this study, we modelled two different BBB systems; a primary human co-culture and a cell line monoculture. These systems were both exposed to three daily repeat doses of morphine and examined for alterations to BBB integrity via permeability, PBMC transmigration, and chemokine gradient changes. We did not find any significant changes to either BBB system with repeat morphine dosing, suggesting that repeat morphine exposure may not play a significant role in BBB changes.
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Details
- Title
- Chronic Low Dose Morphine Does Not Alter Two In Vitro BBB Models
- Creators
- Jamie Marino - Drexel UniversityMonique MaubertJill LawrenceBrian WigdahlMichael Nonnemacher
- Publication Details
- Brain sciences, v 12(7), p888
- Publisher
- MDPI AG
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000832400800001
- Scopus ID
- 2-s2.0-85134032457
- Other Identifier
- 991019168843904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences