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Chronic Pancreatitis and Risk of Atherosclerotic Cardiovascular Disease
Journal article   Peer reviewed

Chronic Pancreatitis and Risk of Atherosclerotic Cardiovascular Disease

Aakash Desai, Saurabh Chandan, Daryl Ramai, Vivek Kaul and Gursimran S. Kochhar
Pancreas, v 52(1), pp e21-e28
01 Jan 2023
DOI: https://doi.org/10.1097/MPA.0000000000002204

Abstract

Gastroenterology & Hepatology Life Sciences & Biomedicine Science & Technology
ObjectivesWorldwide prevalence of chronic pancreatitis (CP) has risen in recent years, with data suggesting an increased risk of atherosclerotic cardiovascular disease (ASCVD) in these patients. We assessed the incidence and risk of ASCVD in patients with CP.MethodsWe compared the risk of ischemic heart disease, cerebrovascular accident, and peripheral arterial disease between CP and non-CP cohorts after propensity matching of known risk factors of ASCVD using TriNetX, a multi-institutional database. We also evaluated the risk of outcomes of ischemic heart disease including acute coronary syndrome, heart failure, cardiac arrest, and all-cause mortality between CP and non-CP cohorts.ResultsChronic pancreatitis cohort was also found to have an increased risk of ischemic heart disease (adjusted odds ratio [aOR], 1.08; 95% confidence interval [CI], 1.03-1.12), cerebrovascular accident (aOR, 1.12; 95% CI, 1.05-1.20), and peripheral arterial disease (aOR, 1.17; 95% CI, 1.1-1.24). Chronic pancreatitis patients with ischemic heart disease were also found to have an increased risk of acute coronary syndrome (aOR, 1.16; 95% CI, 1.04-1.30), cardiac arrest (aOR, 1.24; 95% CI, 1.01-1.53), and mortality (aOR, 1.60; 95% CI, 1.45-1.77).ConclusionsChronic pancreatitis patients are at a higher risk of ASCVD when compared with the general population, matched for confounding etiological, pharmacological, and comorbid variables.

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