Journal article
Chronic Social Stress and Susceptibility to Concentrated Ambient Fine Particles in Rats
Environmental health perspectives, v 118(6), pp 769-775
01 Jun 2010
PMID: 20194079
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Epidemiologic evidence suggests that chronic stress may alter susceptibility to air pollution. However, persistent spatial confounding between these exposures may limit the utility of epidemiologic methods to disentangle these effects and cannot identify physiologic mechanisms for potential differential susceptibilities.
OBJECTIVES: Using a rat model of social stress, we compared respiratory responses to fine concentrated ambient particles (CAPs) and examined biological markers of inflammation.
METHODS: Twenty-four 12-week-old male Sprague-Dawley rats were randomly assigned to four groups [stress/CAPs, stress/filtered air (FA), nonstress/CAPs, nonstress/FA]. Stress-group animals were individually introduced into the home cage of a dominant male twice weekly. Blood drawn at sacrifice was analyzed for immune and inflammatory markers. CAPs were generated using the Harvard ambient particle concentrator, which draws real-time urban ambient fine particles, enriching concentrations approximately 30 times. CAPs/FA exposures were delivered in single-animal plethysmographs, 5 hr/day for 10 days, and respiratory function was continuously monitored using a Buxco system.
RESULTS: Stressed animals displayed higher average C-reactive protein, tumor necrosis factor-cc, and white blood cell counts than did nonstressed animals. Only among stressed animals were CAPs exposures associated with increased respiratory frequency, lower flows, and lower volumes, suggesting a rapid, shallow breathing pattern. Conversely, in animals with elevated CAPs exposures alone, we observed increased inspiratory flows and greater minute volumes (volume of air inhaled or exhaled per minute).
CONCLUSIONS: CAPs effects on respiratory measures differed significantly, and substantively, by stress group. Higher CAPs exposures were associated with a rapid, shallow breathing pattern only under chronic stress. Blood measures provided evidence of inflammatory responses. Results support epidemiologic findings that chronic stress may alter respiratory response to air pollution and may help elucidate pathways for differential susceptibility.
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Details
- Title
- Chronic Social Stress and Susceptibility to Concentrated Ambient Fine Particles in Rats
- Creators
- Jane E. Clougherty - Harvard UniversityChristina A. Rossi - Boston UniversityJoy Lawrence - Boston UniversityMark S. Long - Boston UniversityEdgar A. Diaz - Boston UniversityRobert H. Lim - Boston UniversityBruce McEwen - Rockefeller UniversityPetros Koutrakis - Boston UniversityJohn J. Godleski - Boston University
- Publication Details
- Environmental health perspectives, v 118(6), pp 769-775
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 7
- Grant note
- ES000002 / HSPH NIEHS Bioanalysis Core (National Institutes of Health); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA HSPH National Institute of Environmental Health Sciences (NIEHS) Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P30ES000002 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R-832416 / HSPH Environmental Protection Agency Particle Center
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Dana and David Dornsife School of Public Health; Drexel University; Environmental and Occupational Health
- Web of Science ID
- WOS:000278591300020
- Scopus ID
- 2-s2.0-77953264527
- Other Identifier
- 991020100078004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology