Journal article
Chronic cocaine intoxication alters hippocampal sodium channel function
Neuroscience letters, v 229(2), pp 121-124
1997
PMID: 9223606
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Abstract
Repeated daily administration of subconvulsive doses of cocaine results in the appearance and increase in convulsive responsiveness to the drug and its lethal effects. The mechanisms involved in this increased susceptibility to cocaine-induced seizure are yet unknown. In this study, we used whole cell patch-clamp recording techniques to examine the functional changes in voltage-dependent Na
+ channels produced by subconvulsive doses of cocaine (45 mg/kg per day, i.p.) in rat hippocampal CA1 pyramidal neurons. Intact animals were injected with cocaine for 5–6 days. Acutely dissociated hippocampal neurons were then recorded in vitro. Our results show that an augmentation of peak Na
+ currents and a shift in depolarizing direction of the steady-state inactivation were present in neurons from drug-treated rats. These changes, by making a larger proportion of Na
+ channels available for opening, could increase the excitability of CA1 neurons and may contribute to the increase in convulsive responsiveness to cocaine.
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Details
- Title
- Chronic cocaine intoxication alters hippocampal sodium channel function
- Creators
- Jin ZhaiSteven J WielandFrancis M Sessler
- Publication Details
- Neuroscience letters, v 229(2), pp 121-124
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997XK37100013
- Scopus ID
- 2-s2.0-0030787342
- Other Identifier
- 991014877939704721
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- Web of Science research areas
- Neurosciences