Journal article
Chronic exposure to broadband noise at moderate sound pressure levels spatially shifts tone-evoked responses in the rat auditory midbrain
NeuroImage (Orlando, Fla.), v 122, pp 44-51
15 Nov 2015
PMID: 26232718
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Noise-induced hearing disorders are a significant public health concern. One cause of such disorders is exposure to high sound pressure levels (SPLs) above 85 dBA for eight hours/day. High SPL exposures occur in occupational and recreational settings and affect a substantial proportion of the population. However, an even larger proportion is exposed to more moderate SPLs for longer durations. Therefore, there is significant need to better understand the impact of chronic, moderate SPL exposures on auditory processing, especially in the absence of hearing loss. In this study, we applied functional magnetic resonance imaging (fMRI) with tonal acoustic stimulation on an established broadband rat exposure model (65 dB SPL, 30 kHz low-pass, 60 days). The auditory midbrain response of exposed subjects to 7 kHz stimulation (within exposure bandwidth) shifts dorsolaterally to regions that typically respond to lower stimulation frequencies. This shift is quantified by a region of interest analysis that shows that fMRI signals are higher in the dorsolateral midbrain of exposed subjects and in the ventromedial midbrain of control subjects (p < 0.05). Also, the center of the responsive region in exposed subjects shifts dorsally relative to that of controls (p < 0.05). A similar statistically significant shift (p < 0.01) is observed using 40 kHz stimulation (above exposure bandwidth). The results suggest that high frequency midbrain regions above the exposure bandwidth spatially expand due to exposure. This expansion shifts lower frequency regions dorsolaterally. Similar observations have previously been made in the rat auditory cortex. Therefore, moderate SPL exposures affect auditory processing at multiple levels, from the auditory cortex to the midbrain. (C) 2015 Elsevier Inc. All rights reserved.
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Details
- Title
- Chronic exposure to broadband noise at moderate sound pressure levels spatially shifts tone-evoked responses in the rat auditory midbrain
- Creators
- Condon Lau - City University of Hong KongMartin Pienkowski - Salus UniversityJevin W. Zhang - University of Hong KongBradley McPherson - University of Hong KongEd X. Wu - University of Hong Kong
- Publication Details
- NeuroImage (Orlando, Fla.), v 122, pp 44-51
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- 661313; 17103015 / Hong Kong General Research Fund 11122581 / Hong Kong Health and Medical Research Fund 7200414 / City University of Hong Kong
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Audiology - 4 Year
- Web of Science ID
- WOS:000363125200005
- Scopus ID
- 2-s2.0-84939529988
- Other Identifier
- 991022025114004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging