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Chronic hepatitis: disease factors at diagnosis predictive of mortality
Journal article   Peer reviewed

Chronic hepatitis: disease factors at diagnosis predictive of mortality

B A Lashner, R B Jonas, H S Tang, A A Evans, S E Ozeran and A L Baker
The American journal of medicine, v 85(5), pp 609-614
Nov 1988
DOI: https://doi.org/10.1016/0002-9343(88)90680-8
PMID: 3189363
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Prognosis Humans Middle Aged Risk Factors Aminopyrine - analysis Breath Tests Hepatitis - pathology Male Necrosis Hepatitis - diagnosis Biopsy Hepatitis - metabolism Liver Cirrhosis - pathology Adult Female Chronic Disease Hepatitis - mortality
Chronic hepatitis is known to be a disease with substantial mortality. The purpose of this study was to identify prognostic factors in a large group of patients with chronic hepatitis. We also wanted to determine whether the aminopyrine breath test (ABT) is of additional prognostic value in evaluation of this disease. We studied 94 patients who had had a biopsy-proven diagnosis and an ABT between June 1, 1977, and June 30, 1981. Clinical features and biochemical test results at the time of diagnosis were retrieved from medical records, and histologic severity was assessed by reviewing all liver biopsy specimens under code. Survival was determined at a mean of 60 months. Data were studied with a Cox proportional hazards model to identify predictors of mortality and to control for confounding variables. Cumulative mortality as of December 31, 1985, was 5 percent in chronic persistent hepatitis, 6 percent in chronic active hepatitis, 29 percent in chronic active hepatitis with bridging necrosis, and 53 percent in chronic active hepatitis with cirrhosis. Histologic severity was a predictor of death (p less than 0.005). Other predictors of mortality were disease caused by hepatitis B virus (p less than 0.005), a high alkaline phosphatase level (p less than 0.025), a low alanine aminotransaminase level (p less than 0.001), and a depressed ABT result (p less than 0.005). The results suggest that patients with chronic hepatitis with one or more of these risk factors have an increased mortality and should be followed closely for liver failure, which may necessitate medical therapy or surgical intervention.

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Web of Science research areas
Gastroenterology & Hepatology
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