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Journal article
Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice
Alcohol, v 129, pp 69-78
Dec 2025
PMID: 40972773
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Alcohol use disorder (AUD) and chronic pain are complex and debilitating conditions that are highly comorbid. Greater than 50% of individuals with AUD have chronic pain. Clinical data suggest that people with chronic pain are more likely to report using alcohol to manage chronic pain, and that magnitude of pain is correlated with relapse probability after a period of abstinence. These data led to the hypothesis that pain can drive ethanol seeking and reinstatement in a rodent model of chronic neuropathic pain. A conditioned place preference (CPP) paradigm was used to model ethanol seeking in male C57BL6J mice with a spared nerve injury (SNI). Mice were conditioned with doses of ethanol previously found to reverse pain behavior (0.5g/kg). Mice with and without SNI showed similar magnitudes of ethanol CPP and rates of extinction. To investigate pain-induced relapse-related behavior, mice underwent reinstatement testing following painful mechanical stimulation which was delivered at either a “moderate” or “high” intensity immediately prior to return to the CPP apparatus. “Moderate” painful hindpaw stimulation reinstated ethanol seeking behavior in SNI-injured, but not sham, mice, while “high” intensity stimulation reinstated ethanol seeking in mice regardless of injury status. These data suggest that males in chronic pain are more susceptible reinstatement of ethanol seeking following a painful experience.
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Details
- Title
- Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice
- Creators
- Mitchell Aloysius Nothem - Drexel University, Pharmacology and PhysiologyChristine Marie Side - Drexel University, Pharmacology and PhysiologySimon C. Tran - Drexel UniversityAnaahat Brar - Drexel UniversityLauren Ashley Buck - Drexel University, Pharmacology and PhysiologyJacqueline M Barker (Corresponding Author) - Drexel University, Pharmacology and Physiology
- Publication Details
- Alcohol, v 129, pp 69-78
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- National Institute on Alcohol Abuse and Alcoholism: R21AA027629
Funding This research was supported by the National Institute on Alcohol Abuse and Alcoholism under Award Number R21AA027629 (JMB) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; Pharmacology and Physiology
- Web of Science ID
- WOS:001580271700001
- Scopus ID
- 2-s2.0-105016515859
- Other Identifier
- 991022093052904721
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- Web of Science research areas
- Pharmacology & Pharmacy
- Substance Abuse
- Toxicology