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Published, Version of Record (VoR)CC BY-NC V4.0, Open
Journal article
Chronic recurrent Gorham-Stout syndrome with cutaneous involvement
Rare tumors, v 2(3), pp 109-111
30 Sep 2010
PMCID: PMC2994520
PMID: 21139956
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Type IV osteolysis or Gorham-Stout syndrome is a rare condition characterized by recurrent vascular tumors that disrupt normal anatomical architecture. Gorham-Stout syndrome is most commonly associated with the skeletal system with resulting replacement of bone with scar tissue following tumor regression. The loss of entire bones has given Gorham-Stout syndrome the moniker vanishing bone disease. Natural progression of Gorham-Stout syndrome is characterized by spontaneous disease resolution. However, rare variants of recurrent, progressive, and/or systemic disease have been reported. We present a patient with a history of recurrent Gorham- Stout disease refractory to all treatment options considered. In addition to skeletal disease, our patient had soft tissue and cutaneous involvement, thus reflecting the more aggressive disease variant. Previous surgical attempts to control disease had been ineffective and the patient was referred to us for radiation therapy. Treatment with external beam radiation therapy resulted in good local control and symptom palliation, but full disease resolution was never accomplished. In addition to presentation of this patient, a review of the literature on etiological hypotheses and past/future treatment options was conducted and is included.
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Details
- Title
- Chronic recurrent Gorham-Stout syndrome with cutaneous involvement
- Creators
- Jared Johnstun - Hahnemann University HospitalLuther Brady - Drexel UniversityRebecca Simstein - Temple UniversityNahum Duker - Temple University
- Publication Details
- Rare tumors, v 2(3), pp 109-111
- Publisher
- PagePress
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000219585500002
- Scopus ID
- 2-s2.0-79551624893
- Other Identifier
- 991019169350604721
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- Web of Science research areas
- Oncology