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Journal article
Circadian rhythm in systemic autoimmune conditions: Potential of chrono-immunology in clinical practice: A narrative review
Medicine (Baltimore), v 102(32), e34614
11 Aug 2023
PMID: 37565922
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The circadian rhythm (CR) is a fundamental biological process regulated by the Earth's rotation and solar cycles. It plays a critical role in various bodily functions, and its dysregulation can have systemic effects. These effects impact metabolism, redox homeostasis, cell cycle regulation, gut microbiota, cognition, and immune response. Immune mediators, cycle proteins, and hormones exhibit circadian oscillations, supporting optimal immune function and defence against pathogens. Sleep deprivation and disruptions challenge the regulatory mechanisms, making immune responses vulnerable. Altered CR pathways have been implicated in diseases such as diabetes, neurological conditions, and systemic autoimmune diseases (SADs). SADs involve abnormal immune responses to self-antigens, with genetic and environmental factors disrupting self-tolerance and contributing to conditions like Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Inflammatory Myositis. Dysregulated CR may lead to increased production of pro-inflammatory cytokines, contributing to the systemic responses observed in SADs. Sleep disturbances significantly impact the quality of life of patients with SADs; however, they are often overlooked. The relationship between sleep and autoimmune conditions, whether causal or consequential to CR dysregulation, remains unclear. Chrono-immunology investigates the role of CR in immunity, offering potential for targeted therapies in autoimmune conditions. This paper provides an overview of the connections between sleep and autoimmune conditions, highlighting the importance of recognizing sleep disturbances in SADs and the need for further research into the complex relationship between the CR and autoimmune diseases.
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Details
- Title
- Circadian rhythm in systemic autoimmune conditions: Potential of chrono-immunology in clinical practice: A narrative review
- Creators
- Wireko Andrew Awuah - Sumy State UniversityHelen Huang - Royal College of Surgeons in IrelandJacob Kalmanovich - Drexel UniversityAashna Mehta - University of DebrecenTatiana Mikhailova - SUNY Upstate Medical UniversityJyi Cheng Ng - Universiti Putra MalaysiaToufik Abdul-Rahman - Sumy State UniversityFavour Tope Adebusoye - Sumy State UniversityJoecelyn Kirani Tan - University of St AndrewsKarl Kamanousa - Drexel UniversityTomas Ferreira - University of CambridgeSakshi Roy - Queen's University BelfastMrinmoy Kundu - Institute of Medical Sciences and Sum HospitalRohan Yarlagadda - Rowan UniversityNobendu Mukerjee - West Bengal State UniversityAthanasios Alexiou - Community FoundationMarios Papadakis - Witten/Herdecke University
- Publication Details
- Medicine (Baltimore), v 102(32), e34614
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001046217500082
- Scopus ID
- 2-s2.0-85167678498
- Other Identifier
- 991021868718604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology