Journal article
Circulating Biomarkers for the Early Diagnosis and Management of Hepatocellular Carcinoma with Potential Application in Resource-Limited Settings
Diagnostics (Basel), v 13(4), p676
11 Feb 2023
PMID: 36832164
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hepatocellular carcinoma (HCC) is among the world's third most lethal cancers. In resource-limited settings (RLS), up to 70% of HCCs are diagnosed with limited curative treatments at an advanced symptomatic stage. Even when HCC is detected early and resection surgery is offered, the post-operative recurrence rate after resection exceeds 70% in five years, of which about 50% occur within two years of surgery. There are no specific biomarkers addressing the surveillance of HCC recurrence due to the limited sensitivity of the available methods. The primary goal in the early diagnosis and management of HCC is to cure disease and improve survival, respectively. Circulating biomarkers can be used as screening, diagnostic, prognostic, and predictive biomarkers to achieve the primary goal of HCC. In this review, we highlighted key circulating blood- or urine-based HCC biomarkers and considered their potential applications in resource-limited settings, where the unmet medical needs of HCC are disproportionately highly significant.
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Details
- Title
- Circulating Biomarkers for the Early Diagnosis and Management of Hepatocellular Carcinoma with Potential Application in Resource-Limited Settings
- Creators
- Annabelle Pan - Johns Hopkins MedicineThai N. Truong - Hanoi Medical UniversityYing-Hsiu Su - Baruch S. Blumberg InstituteDoan Y. Dao - Johns Hopkins Medicine
- Publication Details
- Diagnostics (Basel), v 13(4), p676
- Publisher
- Mdpi
- Number of pages
- 17
- Grant note
- Center of Excellence for Liver Disease in Vietnam 800515555 / Johns Hopkins University School of Medicine; Johns Hopkins University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000945207000001
- Scopus ID
- 2-s2.0-85149130742
- Other Identifier
- 991021463593004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology