Journal article
Circulating microRNA Signatures in Rodent Models of Pain
Molecular neurobiology, v 53(5), pp 3416-3427
Jul 2016
PMID: 26081151
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
MicroRNAs (miRNAs) remain stable in circulation and have been identified as potential biomarkers for a variety of conditions. We report miRNA changes in blood from multiple rodent models of pain, including spinal nerve ligation and spared nerve injury models of neuropathic pain; a complete Freund's adjuvant (CFA) model of inflammatory pain; and a chemotherapy-induced model of pain using the histone deacetylase inhibitor JNJ-26481585. The effect of celecoxib, a cyclooxygenase-2-selective nonsteroidal anti-inflammatory drug, was investigated in the CFA model as proof of principle for assessing the utility of circulating miRNAs as biomarkers in determining treatment response. Each study resulted in a unique miRNA expression profile. Despite differences in miRNAs identified from various models, computational target prediction and functional enrichment have identified biological pathways common among different models. The Wnt signaling pathway was affected in all models, suggesting a crucial role for this pathway in the pathogenesis of pain. Our studies demonstrate the utility of circulating miRNAs as pain biomarkers and suggest the potential for rigorous forward and reverse translational approaches. Evaluating alterations in miRNA fingerprints under different pain conditions and after administering therapeutic agents may be beneficial in evaluating clinical trial outcomes, predicting treatment response, and developing correlational outcomes between preclinical and human studies.
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Details
- Title
- Circulating microRNA Signatures in Rodent Models of Pain
- Creators
- Rehman A Qureshi - Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA, 19104, USAYuzhen Tian - Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USAMarguerite K McDonald - Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USAKathryn E Capasso - Albany Medical College, Albany, NY, 12208, USASabrina R Douglas - Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USARuby Gao - Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USAIrina A Orlova - Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USAJames E Barrett - Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USASeena K Ajit - Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USA. seena.ajit@drexelmed.eduAhmet Sacan - School of Biomedical Engineering, Drexel University, Philadelphia, PA, 19104, USA. ahmet.sacan@drexel.edu
- Publication Details
- Molecular neurobiology, v 53(5), pp 3416-3427
- Publisher
- Springer Nature; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology; School of Biomedical Engineering, Science, and Health Systems; Neurology
- Web of Science ID
- WOS:000377935400060
- Scopus ID
- 2-s2.0-84931072158
- Other Identifier
- 991014877769504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences