Journal article
Circulating microRNAs as biomarkers, therapeutic targets, and signaling molecules
Sensors (Basel, Switzerland), v 12(3), pp 3359-3369
2012
PMID: 22737013
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Small noncoding microRNAs (miRNAs) are important regulators of post-transcriptional gene regulation and have altered the prevailing view of a linear relationship between gene and protein expression. Aberrant miRNA expression is an emerging theme for a wide variety of diseases, highlighting the fundamental role played by miRNAs in both physiological and pathological states. The identification of stable miRNAs in bodily fluids paved the way for their use as novel biomarkers amenable to clinical diagnosis in translational medicine. Identification of miRNAs in exosomes that are functional upon delivery to the recipient cells has highlighted a novel method of intercellular communication. Delivery of miRNAs to recipient cells via blood, with functional gene regulatory consequences, opens up novel avenues for target intervention. Exosomes thus offer a novel strategy for delivering drugs or RNA therapeutic agents. Though much work lies ahead, circulating miRNAs are unequivocally ushering in a new era of novel biomarker discovery, intercellular communication mechanisms, and therapeutic intervention strategies.
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Details
- Title
- Circulating microRNAs as biomarkers, therapeutic targets, and signaling molecules
- Creators
- Seena K Ajit - Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. seena.ajit@drexelmed.edu
- Publication Details
- Sensors (Basel, Switzerland), v 12(3), pp 3359-3369
- Publisher
- MDPI; Switzerland
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000302125000059
- Scopus ID
- 2-s2.0-84858973697
- Other Identifier
- 991014878174604721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Analytical
- Engineering, Electrical & Electronic
- Instruments & Instrumentation