Journal article
Circulating tumor HPV DNA assessments after surgery for human papilloma virus-associated oropharynx carcinoma
American journal of otolaryngology, v 45(2), 104184
Mar 2024
PMID: 38101135
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: To understand the utility of circulating tumor human papillomavirus DNA (ctHPVDNA) blood testing for HPV-associated oropharynx squamous cell carcinoma (HPV + OPSCC) after definitive surgery. Materials and methods: Prospective cohort study of HPV(+)OPSCC patients with ctHPVDNA test data to assess its accuracy in detecting biopsy-confirmed disease at various post-treatment time points. Eligible patients had p16 (+)/HPV(+) OPSCC and ctHPVDNA testing performed at any time pre-operatively and/or postoperatively. In cases of recurrence, patients were excluded from analysis if ctHPVDNA testing was not performed within 6 months of biopsy. Results: 196 all-treatment-type patients had at least one PT ctHPVDNA test. The initial post-treatment (PT) ctHPVDNA sensitivity, specificity, PPV, and NPV were 69.2 % (9/13), 96.7 % (177/183), 60.0 % (9/15), and 97.8 % (177/181). 61 surgery alone (SA) patients underwent 128 PT tests. The initial PT SA ctHPVDNA sensitivity, specificity, PPV, and NPV were 100 % (2/2), 96.0 % (48/50), 50 % (2/4), and 100 % (48/48). 35 of 61 (57.4 %) SA patients had NCCN-based histopathologic indications for adjuvant (chemo)radiation but declined. 3 of 35 (8.57 %) had a positive PT ctHPVDNA test of which 1 of 3 (33 %) had biopsy-proven recurrence. Prospectively, ten patients had a PreT positive ctHPVDNA, underwent SA, refused adjuvant treatment, had an undetectable ctHPVDNA within 2 weeks of SA, and remained free of disease (mean 10.3 months). Conclusion: The high specificity and NPV of ctHPVDNA after SA suggest ctHPVDNA may have a role in determining the omission of PT adjuvant (chemo)radiation in select patients.
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Details
- Title
- Circulating tumor HPV DNA assessments after surgery for human papilloma virus-associated oropharynx carcinoma
- Creators
- Spenser S. Souza - Department of Otolaryngology-Head and Neck Surgery, University of California-San Francisco, United States of AmericaErika M. Stephens - University of California, San FranciscoAlexandra T. Bourdillon - University of California, San FranciscoRohith Bhethanabotla - Drexel UniversityZainab Farzal - University of California, San FranciscoKarolina Plonowska-Hirschfeld - University of California, San FranciscoJesse R. Qualliotine - University of California San DiegoChase M. Heaton - University of California San DiegoPatrick K. Ha - University of California San DiegoWilliam R. Ryan (Corresponding Author) - University of California San Diego
- Publication Details
- American journal of otolaryngology, v 45(2), 104184
- Publisher
- W B SAUNDERS CO-ELSEVIER INC; PHILADELPHIA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001137568300001
- Scopus ID
- 2-s2.0-85179945744
- Other Identifier
- 991021861286804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology