Journal article
Circulatory Mechanotherapeutics: Moving with the Force
Current cardiology reports, v 20(10), pp 94-94
01 Oct 2018
PMID: 30136091
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This review describes the current state of advancements in mechanical circulatory support (MCS) devices with significantly improved hemodynamic performance and decreased adverse events. Novel considerations for future MCS designs that impart spiral flow regimes will be detailed.
Significant challenges in MCS device use have included size reduction, premature pump mechanical bearing failure, acquired bleeding disorders, and vascular complications related to high shear forces and jetting. Some of these problems have been improved upon, such as the use of magnetically levitated impellers and hydrodynamic bearings. The relative simplicity of continuous flow pumps has also enabled their miniaturization, portability, and reduced energy consumption. Recent studies by our group demonstrated that spiral forms of flow possess hemodynamically beneficial attributes at the MCS outflow cannula and aorta interface, reducing jet impact, organizing streamlines, and thereby improving endothelial function through wall shear stress modulation.
Despite MCS design improvements, they are far from perfect. Induced spiral fluid modulation may help address the known flow-mediated disturbances in vascular mechanobiology.
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Details
- Title
- Circulatory Mechanotherapeutics: Moving with the Force
- Creators
- Pablo Huang Zhang - Drexel UniversityJ. Yasha Kresh - Drexel University
- Publication Details
- Current cardiology reports, v 20(10), pp 94-94
- Publisher
- Springer Nature
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000442547400002
- Scopus ID
- 2-s2.0-85051853349
- Other Identifier
- 991019169530304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems