Journal article
Click Chemistry in Peptide-Based Drug Design
Molecules (Basel, Switzerland), v 18(8), pp 9797-9817
Aug 2013
PMID: 23959192
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly used to construct diverse chemotypes in both chemical and biological fields. In this review, we discuss the application of click chemistry in peptide-based drug design. We highlight how triazoles formed by click reactions have been used for mimicking peptide and disulfide bonds, building secondary structural components of peptides, linking functional groups together, and bioconjugation. The progress made in this field opens the way for synthetic approaches to convert peptides with promising functional leads into structure-minimized and more stable forms.
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Details
- Title
- Click Chemistry in Peptide-Based Drug Design
- Creators
- Huiyuan Li - Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, 245 N 15th Street, New College Building, Room 11102, Philadelphia, PA 19102, USA; E-MailsRachna Aneja - Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, 245 N 15th Street, New College Building, Room 11102, Philadelphia, PA 19102, USA; E-MailsIrwin Chaiken - Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, 245 N 15th Street, New College Building, Room 11102, Philadelphia, PA 19102, USA; E-Mails
- Publication Details
- Molecules (Basel, Switzerland), v 18(8), pp 9797-9817
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000330304100071
- Scopus ID
- 2-s2.0-84883195229
- Other Identifier
- 991014877902304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary