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Journal article
Clinical Characteristics in Patients with Triple Negative Breast Cancer
International journal of breast cancer, v 2017
2017
PMID: 28912973
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose
. The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis.
Methods
. Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016.
Results
. Out of a total of 1964 patients, 190 (10%) patients had TNBC. The median age for both TNBC and non-TNBC was 59 years. There was a significantly higher proportion of African American and Asian patients with TNBC (
p
=
0.0003
) compared to patients with non-TNBC. BRCA1 and BRCA2 were significantly associated with TNBC (
p
<
0.0001
,
p
=
0.0007
). A prior history of breast cancer was significantly associated with TNBC (
p
=
0.0003
). There was no relationship observed between TNBC and a history of chemoprevention or patients who had a history of AH or LCIS.
Conclusions
. We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC. In order to develop more effective treatments, better surveillance, and improved prevention strategies, it is necessary to improve our understanding of the population at risk for TNBC.
Metrics
Details
- Title
- Clinical Characteristics in Patients with Triple Negative Breast Cancer
- Creators
- Janet Yeh - New York University Langone Medical CenterJennifer Chun - New York University Langone Medical CenterShira Schwartz - New York University Langone Medical CenterAnnie Wang - New York University Langone Medical CenterElizabeth Kern - Drexel UniversityAmber A. Guth - New York University Langone Medical CenterDeborah Axelrod - New York University Langone Medical CenterRichard Shapiro - New York University Langone Medical CenterFreya Schnabel - New York University Langone Medical CenterAlbert S Wang - Mechanical Engineering and Mechanics
- Publication Details
- International journal of breast cancer, v 2017
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000407849800001
- Scopus ID
- 2-s2.0-85028676256
- Other Identifier
- 991019173889504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology