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Clinical-MRI correlations in a multiethnic cohort with recent lacunar stroke: the SPS3 trial
Journal article   Peer reviewed

Clinical-MRI correlations in a multiethnic cohort with recent lacunar stroke: the SPS3 trial

Oscar R. Benavente, Lesly A. Pearce, Carlos Bazan, Ana M. Roldan, Luciana Catanese, Viveca M. Bhat Livezey, Gabriela Vidal-Pergola, Leslie A. McClure, Robert G. Hart and SPS3 Investigators
International journal of stroke, v 9(8), pp 1057-1064
01 Dec 2014
DOI: https://doi.org/10.1111/ijs.12282
PMID: 24862645
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Cardiovascular System & Cardiology Clinical Neurology Life Sciences & Biomedicine Neurosciences & Neurology Peripheral Vascular Disease Science & Technology
Background Neuroimaging manifestations of small vessel disease are heterogeneous, and correlation with patient features has not been adequately characterized. Aim Our goal was to correlate magnetic resonance imaging findings with clinical features in a large multiethnic cohort with recent lacunar stroke. Methods Patient characteristics were correlated with neuroimaging results in the Secondary Prevention of Small Subcortical Stroke study participants. Results Among 3005 patients, mean age was 63 years; 62% were men; and 51%, 30%, and 16% were non-Hispanic White, Hispanic, and Black, respectively. Recent lacunar infarcts were distributed between the subcortical hemisphere (31%), thalamus (26%), brainstem/cerebellum (26%), and basal ganglia/internal capsule (16%). Multiple lacunar infarcts (i.e., acute and remote) were present in 40% and associated with increased age (OR 1.3 per 20 years, 95% CI 1.1, 1.5), male gender (OR 1.5, CI 1.3, 1.7), hypertension (OR 1.5, CI 1.2, 1.8), increased systolic blood pressure (OR 1.2 per 20 mmHg, CI 1.1, 1.3), and prior stroke (OR 3.8, CI 2.9, 5.0). Moderate-severe white matter hyperintensities were present in 50% and associated with increased age (OR 4.3 per 20 years, CI 3.4, 5.4), hypertension (OR 1.8, CI 1.4, 2.3), increased systolic blood pressure (OR 1.3 per 20 mmHg, CI 1.1, 1.5), increased diastolic blood pressure (OR 1.2 per 10 mm, CI 1.0, 1.3), and prior stroke (OR 3.3, CI 2.3, 4.5). Infarct location varied significantly by race-ethnicity (P < 0.001), with Blacks and Hispanics having more infarcts in the brainstem/cerebellum than non-Hispanic Whites, and by gender with women more often having thalamic lacunes than men (P <= 0.001). Conclusions In patients with recent lacunar stroke, infarct location and number have distinctie associations with gender, vascular risk factors, and race-ethnicity, demonstrating the complex pathogenesis of lacunar stroke and cerebral small artery disease.

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20 citations in Web of Science
23 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Clinical Neurology
Peripheral Vascular Disease
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