Journal article
Clinical Practice Guideline for the Management of Infantile Hemangiomas
Pediatrics (Evanston), v 143(1)
01 Jan 2019
PMID: 30584062
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Infantile hemangiomas (IHs) occur in as many as 5% of infants, making them the most common benign tumor of infancy. Most IHs are small, innocuous, self-resolving, and require no treatment. However, because of their size or location, a significant minority of IHs are potentially problematic. These include IHs that may cause permanent scarring and disfigurement (eg, facial IHs), hepatic or airway IHs, and IHs with the potential for functional impairment (eg, periorbital IHs), ulceration (that may cause pain or scarring), and associated underlying abnormalities (eg, intracranial and aortic arch vascular abnormalities accompanying a large facial IH). This clinical practice guideline for the management of IHs emphasizes several key concepts. It defines those IHs that are potentially higher risk and should prompt concern, and emphasizes increased vigilance, consideration of active treatment and, when appropriate, specialty consultation. It discusses the specific growth characteristics of IHs, that is, that the most rapid and significant growth occurs between 1 and 3 months of age and that growth is completed by 5 months of age in most cases. Because many IHs leave behind permanent skin changes, there is a window of opportunity to treat higher-risk IHs and optimize outcomes. Early intervention and/or referral (ideally by 1 month of age) is recommended for infants who have potentially problematic IHs. When systemic treatment is indicated, propranolol is the drug of choice at a dose of 2 to 3 mg/kg per day. Treatment typically is continued for at least 6 months and often is maintained until 12 months of age (occasionally longer). Topical timolol may be used to treat select small, thin, superficial IHs. Surgery and/or laser treatment are most useful for the treatment of residual skin changes after involution and, less commonly, may be considered earlier to treat some IHs.
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Details
- Title
- Clinical Practice Guideline for the Management of Infantile Hemangiomas
- Creators
- Daniel P. Krowchuk - Wake Forest UniversityIlona J. Frieden - University of California, San FranciscoAnthony J. Mancini - Children's Memorial HospitalDavid H. Darrow - Children's Hospital of The King's DaughtersFrancine Blei - Northwell HealthArin K. Greene - Boston Children's HospitalAparna Annam - Children's Hospital ColoradoCynthia N. Baker - Kaiser PermanentePeter C. Frommelt - Children's Hospital of WisconsinAmy Hodak - American Board of Pediatrics, Chapel Hill, North Carolina.Brian M. Pate - University of KansasJanice L. Pelletier - Department of Pediatrics, Northern Light Health, Bangor, Maine.Deborah Sandrock - St. Christopher's Hospital for ChildrenStuart T. Weinberg - Vanderbilt UniversityMary Anne Whelan - Columbia UniversitySUBCOMM MANAGEMENT INFANTILE
- Publication Details
- Pediatrics (Evanston), v 143(1)
- Publisher
- Amer Acad Pediatrics
- Number of pages
- 28
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000454290200053
- Scopus ID
- 2-s2.0-85059369781
- Other Identifier
- 991019168238404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics