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Clinical Subtypes of Frontotemporal Dementia
Journal article   Open access   Peer reviewed

Clinical Subtypes of Frontotemporal Dementia

Sayantani Ghosh and Carol F Lippa
American journal of Alzheimer's disease and other dementias, v 30(7), pp 653-661
Nov 2015
PMID: 23813692
url
https://doi.org/10.1177/1533317513494442View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Behavior - physiology Caregivers - psychology Diagnosis, Differential Frontotemporal Dementia - diagnosis Frontotemporal Dementia - epidemiology Frontotemporal Dementia - genetics Humans Pick Disease of the Brain - diagnosis Pick Disease of the Brain - epidemiology Pick Disease of the Brain - genetics
Frontotemporal dementia (FTD) was one of the lesser known dementias until the recent advancements revealing its genetic and pathological foundation. This common neurodegenerative disorder has three clinical subtypes- behavioral, semantic and progressive non fluent aphasia. The behavioral variant mostly exhibits personality changes, while the other two encompass various language deficits. This review discusses the basic pathology, genetics, clinical and histological presentation and the diagnosis of the 3 subtypes. It also deliberates the different therapeutic modalities currently available for frontotemporal dementia and the challenges faced by the caregivers. Lastly it explores the scope of further research into the diagnosis and management of FTD.

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22 citations in Scopus

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Web of Science research areas
Clinical Neurology
Geriatrics & Gerontology
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