Journal article
Clinical and dosimetric factors associated with a prolonged feeding tube requirement in patients treated with chemoradiotherapy (CRT) for head and neck cancers
Annals of oncology, v 21(1), pp 145-151
01 Jan 2010
PMID: 19602566
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Patients and methods: We retrospectively reviewed 80 patients treated with CRT for head and neck cancers. The pharyngeal constrictors (PCs), supraglottic larynx (SGL), and glottic larynx (GL) were contoured and the mean radiation doses and the volumes of each receiving > 40, 50, 60, and 70 Gy (V40, V50, V60, and V70) were determined.
Results: A total of 33 of 80 patients required a FT either before or during the course of CRT. Fifteen patients required the FT for >= 6 months. On univariate analysis, significant factors associated with a prolonged FT requirement were mean PC dose, PC-V60, PC-V70, SGL dose, SGL-V70, and advanced T3-T4 disease. Multivariate analyses found both PC-V70 and T3-T4 disease as significant factors .The proportions of patients requiring a FT >= 6 months were 8% and 28% for treatment plans with PC-V70 < 30% and >= 30%, respectively.
Conclusions: Increased radiation dose to the PCs is associated with a higher risk of a prolonged FT need. Dose sparing of the PC muscles may reduce this risk.
Metrics
Details
- Title
- Clinical and dosimetric factors associated with a prolonged feeding tube requirement in patients treated with chemoradiotherapy (CRT) for head and neck cancers
- Creators
- A. S. Gokhale - University of PittsburghB. T. McLaughlin - University of PittsburghJ. C. Flickinger - University of PittsburghS. Beriwal - University of PittsburghD. E. Heron - University of PittsburghR. L. Ferris - UPMC Hillman Cancer CenterJ. Johnson - UPMC Hillman Cancer CenterM. K. Gibson - University of PittsburghA. Argiris - University of PittsburghR. P. Smith - University of Pittsburgh
- Publication Details
- Annals of oncology, v 21(1), pp 145-151
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000272924300024
- Scopus ID
- 2-s2.0-75649133685
- Other Identifier
- 991021897372704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology