Journal article
Clinical and neurohormonal characteristics in African Americans with neurogenic orthostatic hypotension
Clinical autonomic research, v 31(1), pp 101-107
01 Feb 2021
PMID: 33502643
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose
Neurogenic orthostatic hypotension (nOH) is the hallmark of neurodegenerative forms of autonomic failure, including pure autonomic failure, multiple system atrophy, and Parkinson's disease. Studies have shown autonomic physiological differences in Africans Americans (AA) such as lower heart rate variability, enhanced blood pressure reactivity, and blunted sympathetic neural response compared to non-Hispanic whites. However, the clinical characteristics and neurohormonal profile of autonomic failure in AA is unknown.
Methods
A total of 65 patients with nOH participated in this study (9 AA and 56 non-Hispanic whites). Both groups were of similar age and comorbidity status, and they underwent standardized autonomic testing and assessment of neurohormonal levels and renin activity and aldosterone in supine and upright positions.
Results
There were no significant differences in baseline autonomic clinical characteristics between non-Hispanic whites and AA with nOH. Non-Hispanic whites demonstrated a significant increase in upright renin activity compared to AA (295 +/- 88% vs. 13 +/- 13%, respectively). AA showed a blunted increase in aldosterone compared to non-Hispanic whites (188 +/- 27% vs. 59 +/- 38%, respectively). These results indicated persistent suppression of the renin-angiotensin system in AA, particularly during upright posture.
Conclusion
Our findings demonstrate that AA with nOH have similar clinical characteristics and hemodynamic autonomic profiles, but lower upright renin activity and aldosterone levels, compared to non-Hispanic whites. Renin suppression persists in AA with severe autonomic failure and can potentially contribute to postural changes and supine hypertension.
Metrics
1 Record Views
1 citations in Scopus
Details
- Title
- Clinical and neurohormonal characteristics in African Americans with neurogenic orthostatic hypotension
- Creators
- Richard J. Giza - Drexel UniversityMaureen C. Farrell - Drexel UniversityAmy C. Arnold - Penn State Milton S. Hershey Medical CenterItalo Biaggioni - Vanderbilt University Medical CenterCyndya A. Shibao - Vanderbilt University Medical Center
- Publication Details
- Clinical autonomic research, v 31(1), pp 101-107
- Publisher
- Springer Nature
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000612244500001
- Scopus ID
- 2-s2.0-85099754880
- Other Identifier
- 991021860759004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences