Journal article
Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort
Annals of the rheumatic diseases, v 72(8), pp 1308-1314
01 Aug 2013
PMID: 22945501
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS.
Methods The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS.
Results We studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2years (13.4) and 24.1weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS.
Conclusions Renal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients.
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Details
- Title
- Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort
- Creators
- Ben Parker - Centre for Inflammation ResearchMurray B. Urowitz - Toronto Western HospitalDafna D. Gladman - Toronto Western HospitalMark Lunt - University of ManchesterSang-Cheol Bae - Hanyang UniversityJorge Sanchez-Guerrero - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránJuanita Romero-Diaz - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránCaroline Gordon - University of BirminghamDaniel J. Wallace - Cedars-Sinai Medical CenterAnn E. Clarke - McGill University Health CentreSasha Bernatsky - Montreal General HospitalEllen M. Ginzler - SUNY Downstate Health Sciences UniversityDavid A. Isenberg - University College LondonAnisur Rahman - University College LondonJoan T. Merrill - Oklahoma Medical Research FoundationGraciela S. Alarcon - University of Alabama at BirminghamBarri J. Fessler - University of Alabama at BirminghamPaul R. Fortin - Centre hospitalier universitaire de QuébecJohn G. Hanly - Queen Elizabeth II Health Sciences CentreMichelle Petri - Johns Hopkins UniversityKristjan Steinsson - Reykjavík UniversityMary-Anne Dooley - University of North Carolina at Chapel HillSusan Manzi - College Station Medical CenterMunther A. Khamashta - St Thomas' HospitalRosalind Ramsey-Goldman - Northwestern UniversityAsad A. Zoma - Hairmyres HospitalGunnar K. Sturfelt - Lund UniversityOla Nived - Lund UniversityCynthia Aranow - Feinstein Institute for Medical ResearchMeggan Mackay - Feinstein Institute for Medical ResearchManuel Ramos-Casals - Consorci Institut D'Investigacions Biomediques August Pi I SunyerRaymond F. van Vollenhoven - Karolinska InstitutetKenneth C. Kalunian - University of California, San DiegoGuillermo Ruiz-Irastorza - Hospital de CrucesSam Lim - Emory UniversityDiane L. Kamen - Medical University of South CarolinaChristine A. Peschken - University of ManitobaMurat Inanc - Istanbul UniversityIan N. Bruce - Manchester Academic Health Science Centre
- Publication Details
- Annals of the rheumatic diseases, v 72(8), pp 1308-1314
- Publisher
- Bmj Publishing Group
- Number of pages
- 7
- Grant note
- Arthritis Research clinical research fellowship; Versus Arthritis NF-SI-0512-10105 / National Institute for Health Research; National Institutes of Health Research (NIHR) Department of Education, Universities and Research, Basque Government; Basque Government NIHR Manchester Biomedical Research Centre; National Institutes of Health Research (NIHR) 93695 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) Singer Family Fund for Lupus Research RD-1 43727 / Hopkins Lupus Cohort NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Arthritis Research UK (Arthritis Research UK Epidemiology Unit core support programme grant); Versus Arthritis National Institute for Health Research Biomedical Research Unit funding scheme UL1 RR025741; P60AR 30692; K24 AR 002138 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000321338400010
- Scopus ID
- 2-s2.0-84880214160
- Other Identifier
- 991021933910104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology