Journal article
Clinical characteristics of antiphospholipid antibody syndrome in children
The Journal of pediatrics, v 129(3), pp 339-345
01 Sep 1996
PMID: 8804321
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE: To evaluate the clinical features and outcome of antiphospholipid syndrome (APS) in children.
STUDY DESIGN: Retrospective chart review of patients seen at the Children's Hospital of Philadelphia and Children's Seashore House Pediatric Rheumatology Center between 1988 and 1993.
RESULTS: Nine patients with ages ranging from 8 months to 17 years are presented. Clinical features of five patients with primary APS, described in detail, were digital ischemia, stroke, chorea, Addison disease, and pulmonary vaso-occlusive disease. The four children with secondary APS had systemic lupus erythematosus. Clinical features of these patients include livedo reticularis, deep venous thrombosis, and pulmonary hypertension. Antiphospholipid titers, results of coagulation studies, and serologic findings did not predict outcome.
CONCLUSION: APS in children has diverse clinical features similar to those in adults and should be considered in cases of unexplained vaso-occlusive disease.(J P
EDIATR 1996;129:339-45)
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Details
- Title
- Clinical characteristics of antiphospholipid antibody syndrome in children
- Creators
- Emily von SchevenBalu H. AthreyaCarlos D. RoseDonald P. GoldsmithLawrence Morton
- Publication Details
- The Journal of pediatrics, v 129(3), pp 339-345
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:A1996VK79800004
- Scopus ID
- 2-s2.0-0030411599
- Other Identifier
- 991021838615204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics