Journal article
Clinical features and postoperative seizure outcome in patients with drug-resistant gelastic seizures without hypothalamic hamartoma
Epilepsy & behavior, v 64(Pt A), pp 90-93
01 Nov 2016
PMID: 27736662
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: The objective of this study was to describe the clinical characteristics and surgical outcome in patients with gelastic seizures without hypothalamic hamartoma.
Methods: We retrospectively reviewed all the video-EEG reports over a 5-year period (2007-2011) for the occurrence of the terms "laugh" or "giggle" in the text body. All the patients with at least one documented gelastic seizure at the epilepsy monitoring unit were studied. In patients who underwent epilepsy surgery, seizure outcomes were analyzed.
Results: Sixteen patients (10 females and 6 males) with a mean age of 46.3 years were studied. Seven patients had invasive intracranial EEG recordings. Seizure onset zone was in a temporal lobe in four patients and the frontal lobe in one patient. Two patients did not have gelastic seizures during their intracranial EEG monitoring. Nine patients underwent resective epilepsy surgery for their seizures. Six patients (67%) were seizure-free after surgery.
Conclusion: In adult patients, gelastic seizures can be seen in patients with focal epilepsy without hypothalamic hamartoma. Nonhypothalamic hamartoma gelastic seizures originating from the temporal lobe can be amenable to surgery. (C) 2016 Elsevier Inc. All rights reserved.
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Details
- Title
- Clinical features and postoperative seizure outcome in patients with drug-resistant gelastic seizures without hypothalamic hamartoma
- Creators
- Camilo Gutierrez - Temple University HospitalAli A. Asadi-Pooya - Comprehensive Epilepsy CenterChristopher T. Skidmore - Comprehensive Epilepsy CenterSteven D. Tobochnik - Columbia University Medical CenterCarla LoPinto-Khoury - Drexel UniversityMichael R. Sperling - Comprehensive Epilepsy Center
- Publication Details
- Epilepsy & behavior, v 64(Pt A), pp 90-93
- Publisher
- Elsevier
- Number of pages
- 4
- Grant note
- Eisai; Eisai Co Ltd UCB Pharma; UCB Pharma SA Accorda Sunovion Brain Sentinel Marinus Glaxo Neuropace through Thomas Jefferson University Upsher-Smith Pfizer through Thomas Jefferson University SIC Life Sciences Medtronics
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000389734800016
- Scopus ID
- 2-s2.0-84991449444
- Other Identifier
- 991019168637304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Clinical Neurology
- Psychiatry