Journal article
Clinical manifestations and treatment of antisynthetase syndrome
Best practice & research. Clinical rheumatology, v 34(4), 101503
Aug 2020
PMID: 32284267
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antisynthetase syndrome (ASyS) is an autoimmune disease clinically manifested most often by interstitial lung disease, myositis, and arthritis. Raynaud's syndrome, fever, and rashes are also commonly seen. This syndrome is characterized by the highly specific presence of antibodies against various aminoacyl transfer RNA synthetases, including Jo-1 and others. In this chapter, we provide an overview of ASyS, including pathogenesis, common clinical manifestations, and treatment strategies. We discuss the spectrum of disease seen with specific antisynthetase antibodies and examine the differences in phenotype between patients with different antisynthetase antibodies. We outline common treatment strategies, which should generally target the most severe and life- or organ-threatening disease manifestations. Finally, we discuss short- and long-term prognosis in ASyS.
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Details
- Title
- Clinical manifestations and treatment of antisynthetase syndrome
- Creators
- Joanna L. Marco - University of WashingtonBridget F. Collins - University of Washington
- Publication Details
- Best practice & research. Clinical rheumatology, v 34(4), 101503
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000582800400005
- Scopus ID
- 2-s2.0-85083004167
- Other Identifier
- 991021448167004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Rheumatology