Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Clinical myocardial recovery in advanced heart failure with long term left ventricular assist device support
The Journal of heart and lung transplantation, v 41(10), pp 1324-1334
01 Oct 2022
PMID: 35835680
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Left ventricular assist-device (LVAD) implantation is a life-saving therapy for patients with advanced heart failure (HF). With chronic unloading and circulatory support, LVAD-supported hearts often show significant reverse remodeling at the structural, cellular and molecular level. However, translation of these changes into meaningful cardiac recovery allowing LVAD explant is lagging. Part of the reason for this discrepancy is lack of anticipation and hence promotion and evaluation for recovery post LVAD implant. There is additional uncertainty about the long-term course of HF following LVAD explant. In selected patients, however, guided by the etiology of HF, duration of disease and other clinical factors, significant functional improvement and LVAD explantation with long-term freedom from recurrent HF events has been demonstrated to be feasible in a reproducible manner. The identified predictors of myocardial recovery suggest that the elective therapeutic use of potentially less invasive VADs for reversal of HF earlier in the disease process is a future goal that warrants further investigation. Hence, it is prudent to develop and implement tools to predict HF reversibility prior to LVAD implant, optimize unloading-promoted recovery with guideline directed medical therapy and monitor for myocardial improvement. This review article summarizes the clinical aspects of myocardial recovery and together with its companion review article focused on the biological aspects of recovery, they aim to provide a useful framework for clinicians and investigators.
Metrics
Details
- Title
- Clinical myocardial recovery in advanced heart failure with long term left ventricular assist device support
- Creators
- Manreet K. Kanwar - Allegheny Health NetworkCraig H. Selzman - University of UtahVan-Khue Ton - Harvard Medical SchoolOliver Miera - Deutsches Herzzentrum MünchenWilliam K. Cornwell - University of Colorado Anschutz Medical CampusJames Antaki - Cornell UniversityStavros Drakos - University of UtahPalak Shah - Alaska Heart and Vascular Institute
- Publication Details
- The Journal of heart and lung transplantation, v 41(10), pp 1324-1334
- Publisher
- Elsevier
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiology
- Web of Science ID
- WOS:000890980000005
- Scopus ID
- 2-s2.0-85134319025
- Other Identifier
- 991021932103104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery
- Transplantation