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Clinical outcomes of atrial fibrillation with hyperthyroidism
Journal article   Open access   Peer reviewed

Clinical outcomes of atrial fibrillation with hyperthyroidism

Muhammad Zubair Khan, Ashwani Gupta, Jordesha Hodge, Kirtenkumar Patel, Krunalkumar Patel, Muhammad Samsoor Zarak, Sona Franklin, Harsh Patel, Shruti Jesani, Sejal Savani, …
Journal of arrhythmia, v 37(4), pp 942-948
Aug 2021
DOI: https://doi.org/10.1002/joa3.12550
PMID: 34386120
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/joa3.12550View
Published, Version of Record (VoR) Open
url
https://doi.org/10.1002/joa3.12550View
Published, Version of Record (VoR) Open

Abstract

arrhythmia atrial fibrillation hyperthyroidism
Background Atrial fibrillation (Afib) is a common cardiac manifestation of hyperthyroidism. The data regarding outcomes of Afib with and without hyperthyroidism are lacking. Hypothesis We hypothesized that patients with Afib and hyperthyroidism have better clinical outcomes, compared with Afib patients without hyperthyroidism. Methods We queried the National Inpatient Sample database for years 2015‐2017 using Validated ICD‐10‐CM codes for Afib and hyperthyroidism. Patients were separated into two groups, Afib with hyperthyroidism and without hyperthyroidism. Results The study was conducted with 68 095 278 patients. A total of 9 727 295 Afib patients were identified, 90 635 (0.9%) had hyperthyroidism. The prevalence of hyperthyroidism was higher in patients with Afib (0.9% vs 0.4%, P < .001), compared with patients without Afib. Using multivariate regression analysis adjusting for various confounding factors, the odds ratio of Afib with hyperthyroidism was 2.08 (CI 2.07‐2.10; P < .0001). Afib patients with hyperthyroidism were younger (71 vs 75 years, P < .0001) and more likely to be female (64% vs 47%; P < .0001) as compared with Afib patients without hyperthyroidism. Afib patients with hyperthyroidism had lower prevalence of CAD (36% vs 44%, P < .0001), cardiomyopathy (24.1% vs 25.9%, P < .0001), valvular disease (6.9% vs 7.4%, P < .0001), hypertension (60.7% vs 64.4%, P < .0001), diabetes mellitus (29% vs 32%, P < .0001) and obstructive sleep apnea (10.5% vs 12.2%, P < .0001). Afib with hyperthyroidism had lower hospitalization cost ($14 968 ± 21 871 vs $15 955 ± 22 233, P < .0001), shorter mean length of stay (5.7 ± 6.6 vs 5.9 ± 6.6 days, P < .0001) and lower in‐hospital mortality (3.3% vs 4.8%, P < .0001. The disposition to home was higher in Afib with hyperthyroidism patients (51% vs 42; P < .0001). Conclusion Hyperthyroidism is associated with Afib in both univariate and multivariate analysis. Afib patients with hyperthyroidism have better clinical outcomes, compared with Afib patients without hyperthyroidism. Atrial fibrillation (Afib) is a common cardiac manifestation of hyperthyroidism. The data regarding clinical outcomes of Afib with and without hyperthyroidism are lacking.

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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