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Clinical significance of a cytologic diagnosis of atypical glandular cells, favor endometrial origin, in Pap smears
Journal article   Peer reviewed

Clinical significance of a cytologic diagnosis of atypical glandular cells, favor endometrial origin, in Pap smears

Reda S Saad, Hidehero Takei, Yulin L Liu, Jan E Silverman, Jane T Lipscomb, Bernardo Ruiz and Jan F Silverman
Acta cytologica, v 50(1), pp 48-54
Jan 2006
DOI: https://doi.org/10.1159/000325894
PMID: 16514840
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adult Aged Aged, 80 and over Biopsy Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Endometrial Hyperplasia - diagnosis Endometrial Hyperplasia - pathology Endometrial Neoplasms - diagnosis Endometrial Neoplasms - pathology Endometrium - pathology Female Humans Metaplasia - diagnosis Metaplasia - pathology Middle Aged Papanicolaou Test Polyps - diagnosis Polyps - pathology Retrospective Studies Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - pathology Vaginal Smears
To evaluate the significance of a diagnosis of atypical glandular cells, favor endometrial origin (AGC-EM), using cytohistologic correlation. A retrospective search identified 90 cervicovaginal smears (vaginal pool) with a diagnosis of AGC-EM, in 2 tertiary care medical centers between January 1998 and December 2002. Forty-six (51%) were conventional preparations and 44 (49%) were liquid-based monolayers (SurePath, TriPath Imaging Inc., Burlington, North Carolina, U.S.A.). Follow-up biopsies were available in 55 of 90 (61%) cases, 15 of 90 (17%) cases had cytology follow-up, and 20 of 90 (22%) were lost to follow-up. The patients ranged in age from 30 to 86 years (mean, 56); 56 of 90 (62%) were > 50 years. Among the patients who underwent biopsy, 22 (40%) had a clinically significant lesion, including 10 (18%) endometrial adenocarcinomas, 8 (15%) endometrial hyperplasias and 4 (7%) high grade squamous intraepithelial lesion/squamous cell carcinoma, nonkeratinizing type. The remaining 33 patients had benign histology, including benign endometrium, endometrial polyp, tubal metaplasia, cystic endometrial atrophy and cervical microglandular hyperplasia. Of the patients with cytologic follow-up, 2 had Pap smears showing atypical squamous cells of undetermined significance, while the remainder had negative results. In our study population, 40% (22 of 55) of women who underwent biopsy following a diagnosis of AGC-EM had significant uterine lesions, with the majority of the lesions endometrial in origin. Patients with a diagnosis of AGC-EM, especially those > 50, should be followed closely, and endometrial sampling should be included in their initial workup.

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UN Sustainable Development Goals (SDGs)

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#5 Gender Equality
#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Pathology
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