Journal article
Clinical significance of cytologic diagnosis of atypical squamous cells, cannot exclude high grade, in perimenopausal and postmenopausal women
American journal of clinical pathology, v 126(3), pp 381-388
01 Sep 2006
PMID: 16880134
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We used cytohistologic correlation to determine the clinical significance of atypical squamous cells, cannot exclude high grade (ASC-H), in perimenopausal and postmenopousal women. A computer search identified 250 Papanicolaou smears from women older than 45 years with a diagnosis of ASC-H. Cases were considered perimenopausal (45 to < 55years; 150 cases) and postmenopausal (>= 55 years; 100 cases). No follow-up data were available for 33 cases, which were excluded. The remaining 217 cases (perimenopausal, 127; postmenopausal, 90) had surgical or cytologic follow-up. Results of follow-up colposcopic biopsy were available for 176 (81.1 %) and cytology for 41 (18.9%) women. Follow-up results were as follows: perimenopousal women, negative, 50 (39.4%); mild dysplasia (low-grade squamous intraepithelial lesion [LSIL]), 46 (36.2%); high-grade dysplasia (high-grade SIL [HSIL]); 28 (22.0%); and ASC of undetermined significance (ASC-US), 3 (2.4%); postmenopausal women, negative, 52 (58%); LSIL, 31 (34%); HSIL, 5 (6%); and ASC-US, 2 (2%). The diagnosis of ASC-H in postmenopausal women usually is associated with LSIL or a negative diagnosis on follow-up, suggesting a less aggressive surveillance and treatment regimen is needed for postmenopausal women with ASC-H.
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Details
- Title
- Clinical significance of cytologic diagnosis of atypical squamous cells, cannot exclude high grade, in perimenopausal and postmenopausal women
- Creators
- Reda S. Saad - Allegheny General HospitalDavid J. Dabbs - Magee-Womens HospitalLana Kordunsky - Allegheny General HospitalAmal Kanbour-Shakir - Magee-Womens HospitalJan F. Silverman - Drexel UniversityYulin Liu - Allegheny General HospitalAnisa Kanbour - Magee-Womens Hospital
- Publication Details
- American journal of clinical pathology, v 126(3), pp 381-388
- Publisher
- Amer Soc Clinical Pathology
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000239910500008
- Scopus ID
- 2-s2.0-33748359093
- Other Identifier
- 991019168021804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pathology