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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions-A systematic review
Journal of surgical oncology, v 117(2)
Feb 2018
PMID: 29120491
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The field of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has suffered from a lack of clinical trials to validate its expanding use.
To evaluate published and ongoing clinical trials seeking to better define role of CRS/HIPEC in the treatment of peritoneal surface malignancies.
Systematic review by PubMed search was performed using terms "Clinical trial," "intraperitoneal chemotherapy," and "HIPEC." ClinicalTrials.gov and EudraCT registries were searched for active clinical trials. Eligibility included CRS/HIPEC trials investigating adult patient populations from published clinical reports and/or trials currently accruing or at completion.
Thirteen published trials and 57 active clinical trials were included for review.
Published and ongoing U.S. and international clinical trials for CRS and HIPEC are defining important parameters that include improving patient selection, strategic sequences of treatment, cytoreductive strategies, chemotherapeutics, optimal hyperthermic temperature and timing, and toxicity profiles. Main barriers or limitations to trial development remain patient enrollment, trial design, and oncologic community collaboration. Overall progress is positive with increasing number of clinical trials throughout the world. Collaboration between surgeons and the wider oncologic community will be crucial to validate this important treatment strategy.
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Details
- Title
- Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions-A systematic review
- Creators
- William F Morano - Drexel UniversityMarian Khalili - Drexel UniversityDennis S Chi - Memorial Sloan Kettering Cancer CenterWilbur B Bowne - Drexel UniversityJesus Esquivel - Department of Surgery; Frederick Memorial Hospital; Frederick MarylandSarah S Long - Pediatrics
- Publication Details
- Journal of surgical oncology, v 117(2)
- Publisher
- Wiley
- Grant note
- P30 CA008748 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000426165700018
- Scopus ID
- 2-s2.0-85042496919
- Other Identifier
- 991019353630904721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Surgery