Journal article
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review
The American surgeon, v 84(2)
01 Feb 2018
PMID: 29580358
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Appendiceal mucoceles (AMs) are rare mucin-containing neoplasms with malignant potential. Lack of evidence-based data exists defining clinicopathological features for management. MEDLINE search between 1995 and 2015 was performed using search criteria "Appendix mucocele." Systematic review of patient-, pathologic-, and treatment-related characteristics was performed and data analyzed. Among 276 cases of non-perforated AMs, 163 (59%) patients were female, with variable and nonspecific presentation. Patients were treated with appendectomy (52.1%), right hemicolectomy (17.6%), partial cecectomy (17.2%), and ileocecetomy (13.1%). Pathologic evaluation revealed the following: cystadenoma/low-grade appendiceal mucinous neoplasm (54%), unspecified/benign (25%), retention cyst (14.1%), cystadenocarcinoma (4.2%), and mucosal hyperplasia (2.9%). All 11 (4.2%) patients with cystadenocarcinoma were female (P = 0.004), odds ratio for malignancy 1.07 times higher for women. Synchronous colonic malignancy was reported in three patients (27%) with cystadenocarcinoma (P = 0.007), odds ratio of 12.1. AMs have low risk for malignancy. Treatment should begin with appendectomy-only and subsequently guided by pathologic diagnosis.
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Details
- Title
- Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review
- Creators
- William F. Morano - Drexel UniversityElizabeth M. Gleeson - Drexel UniversitySean H. Sullivan - Drexel UniversityVennila Padmanaban - Drexel UniversityBeth L. Mapow - Drexel UniversityPatricia A. Shewokis - Drexel UniversityJesus Esquivel - Department of Surgery; Frederick Memorial Hospital; Frederick MarylandWilbur B. Bowne - Drexel University
- Publication Details
- The American surgeon, v 84(2)
- Publisher
- Southeastern Surgical Congress
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nutrition Sciences
- Web of Science ID
- WOS:000426593400037
- Scopus ID
- 2-s2.0-85042858204
- Other Identifier
- 991019167944704721
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- Web of Science research areas
- Surgery