Journal article
Clonal trisomy 4 cells detected in the ossifying renal tumor of infancy: study of 3 cases
Modern pathology, v 26(2), pp 275-281
Feb 2013
PMID: 22976287
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ossifying renal tumor of infancy is a rare neoplasm diagnosed in the first 2 years of life, predominantly in boys. The neoplasm is primarily characterized by the presence of a large ossifying component. Its most common mode of presentation is hematuria, and it has a uniformly benign behavior. The karyotypic makeup of the process has not been reported. Thus, a study was undertaken and it allowed demonstration of clonal trisomy 4, which was confirmed by the fluorescent in-situ hybridization-probing of two additional archival formalin-fixed, paraffin-imbedded similar tumors. On the basis of the findings in these three cases, it seems that clonal trisomy 4 may be considered as a characteristic of the tumor, which makes it distinct from any other infantile renal tumor.
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Details
- Title
- Clonal trisomy 4 cells detected in the ossifying renal tumor of infancy: study of 3 cases
- Creators
- Jinglan Liu - St. Christopher's Hospital for ChildrenMiguel A Guzman - Department of Pathology and Laboratory Medicine, Drexel University College of Medicine and St Christopher's Hospital for Children, Philadelphia, USABruce R Pawel - Children's Hospital of PhiladelphiaDonna M Pezanowski - Department of Pathology and Laboratory Medicine, Drexel University College of Medicine and St Christopher's Hospital for Children, Philadelphia, USADilipkumar M Patel - Department of Pathology and Laboratory Medicine, Drexel University College of Medicine and St Christopher's Hospital for Children, Philadelphia, USAJonathan A Roth - St. Christopher's Hospital for ChildrenGregory E Halligan - St. Christopher's Hospital for ChildrenJean-Pierre de Chadarévian - Department of Pathology and Laboratory Medicine, Drexel University College of Medicine and St Christopher's Hospital for Children, Philadelphia, USA
- Publication Details
- Modern pathology, v 26(2), pp 275-281
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000314444000014
- Scopus ID
- 2-s2.0-84873412428
- Other Identifier
- 991019168814504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pathology