Journal article
Cloning and Characterization of the Human Retinoid X Receptor alpha Gene: Conservation of Structure with the Mouse Homolog
Biochemical and biophysical research communications, v 269(1), pp 54-57
05 Mar 2000
PMID: 10694476
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Retinoid X receptors (RXRs) are members of the steroid/thyroid hormone receptor superfamily which, along with retinoic acid receptors (RARs), mediate the biological effects of retinoids. These effects include the regulation of many aspects of embryonic development, reproductive and visual function, and the maintenance of epithelial homeostasis throughout life. The genes for three distinct retinoid X receptors, RXR alpha , beta , and gamma , have been localized to separate chromosomes. In order to determine the organization of the human RXR alpha gene, we have isolated a clone containing the majority of the gene from a human genomic bacterial artificial chromosome (BAC) library and generated a physical map. The gene spans over 40 kilobases in size and contains at least 10 exons. Comparison with mapped portions of the mouse RXR alpha gene indicates highly conserved intron-exon positioning. These results provide information necessary to generate constructs for targeting the RXR alpha gene in human cell lines, which may eventually lead to an understanding of the function of RXR alpha in human cancer. Copyright 2000 Academic Press.
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Details
- Title
- Cloning and Characterization of the Human Retinoid X Receptor alpha Gene: Conservation of Structure with the Mouse Homolog
- Creators
- G Li - Head & Neck SurgeryE Walch - The University of Texas MD Anderson Cancer CenterX Yang - The University of Texas MD Anderson Cancer CenterS Lippman - The University of Texas MD Anderson Cancer CenterJ Clifford - The University of Texas MD Anderson Cancer Center
- Publication Details
- Biochemical and biophysical research communications, v 269(1), pp 54-57
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000085918600010
- Scopus ID
- 2-s2.0-0034607133
- Other Identifier
- 991020202346504721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics