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Journal article
Cloning of myelin basic protein-reactive T cells from the experimental allergic encephalomyelitis-resistant rat strain, LER
Journal of neuroimmunology, v 59(1), pp 173-183
1995
PMID: 7541054
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Abstract
Rats of the LER inbred strain are resistant to the active induction of experimental allergic encephalomyelitis (EAE), although they are susceptible to adoptively transferred EAE when they are injected with encephalitogenic T cells from EAE-susceptible Lewis rats. The mechanism of resistance remains to be elucidated. We report here that myelin basic protein (MBP)-specific T cells can be cloned from LER rats immunized with MBP, that these CD4
+ LER T cells can recognize the encephalitogenic peptide (MBP-EP) and will divide vigorously when it is presented to them, and that these T cells bear Vβ8 + TCR chains. Nevertheless, in contrast to Lewis T cells with the same specificity and TCR β chains, LER T cells from MBP-EP-specific clones cannot induce EAE when adoptively transferred into naive rats of either strain. Thus, LER T cells can assemble and use a TCR with the canonical encephalitogenic Vβ8.2-Dβ-Jβ region in response to immunization with MBP, yet they continue to display resistance to EAE.
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Details
- Title
- Cloning of myelin basic protein-reactive T cells from the experimental allergic encephalomyelitis-resistant rat strain, LER
- Creators
- Elizabeth P Blankenhorn - Department of Microbiology and Immunology, Hahnemann University, Philadelphia, PA 19102, USASharon A Stranford - Department of Microbiology and Immunology, Hahnemann University, Philadelphia, PA 19102, USAAnne-Marie Martin - Department of Microbiology and Immunology, Hahnemann University, Philadelphia, PA 19102, USAWilliam F Hickey - Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
- Publication Details
- Journal of neuroimmunology, v 59(1), pp 173-183
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1995RE73600019
- Scopus ID
- 2-s2.0-0029011938
- Other Identifier
- 991014878291104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences