Journal article
Coacervation-triggered hierarchically assembled hydrogels with application as surgical sealant
Biofabrication, v 15(3), 035021
01 Jul 2023
PMID: 37285837
Abstract
Adhesive hydrogels possess great potential to be explored as tissue adhesives, surgical sealants, and hemostats. However, it has been a great challenge to develop hydrogels that can function rapidly and controllably on wet, dynamic biological tissues. Inspired by polyphenol chemistry, we introduce a coacervation-triggered shaping strategy that enables the hierarchical assembly of recombinant human collagen (RHC) and tannic acid (TA). The conformation of the RHC and TA aggregates is controlled to evolve from granular to web-like states, accompanied by the significant enhancement of mechanical and adhesion performance. The coacervation and assembly process is driven by intermolecular interactions, especially hydrogen bonding between RHC and TA. Benefitting from the multifaceted nature of polyphenol chemistry, the hierarchically assembled hydrogels revealed excellent properties as surgical sealing materials, including fast gelation time (within 10 s), clotting time (within 60 s), ultrastretchability (strain >10 000%), and tough adhesion (adhesive strength >250 kPa). In vivo experiments demonstrated complete sealing of severely leaking heart and liver tissues with the assistance of in situ formed hydrogels during 7 d of follow-up. This work presents a highly promising hydrogel-based surgical sealant in wet and dynamic biological environments for future biomedical applications.
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Details
- Title
- Coacervation-triggered hierarchically assembled hydrogels with application as surgical sealant
- Creators
- Zhongwei Guo - Zhengzhou Univ, Sch Mech & Safety Engn, Zhengzhou 450001, Peoples R ChinaZunghang Wei - Zhengzhou UniversityWei Sun - Tsinghua University
- Publication Details
- Biofabrication, v 15(3), 035021
- Publisher
- IOP Publishing Ltd
- Number of pages
- 18
- Grant note
- 32213281 / Initial Scientific Research Fund of Young Teachers in Zhengzhou University 2016YFC1100100 / projects of National Key Research and Development Program of China; National Key Research & Development Program of China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:001008380700001
- Scopus ID
- 2-s2.0-85163796296
- Other Identifier
- 991021860722504721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials