Journal article
Cobalt stimulates carotid body chemoreceptors
Journal of applied physiology (1985), v 68(5), pp 1844-1849
01 May 1990
PMID: 2361886
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Abstract
Because cobalt administration is known to elicit erythropoietin response, it is a reasonable hypothesis that cobalt would also stimulate the O2-sensing process in the peripheral chemoreceptors. We tested this hypothesis by measuring the effects of cobalt chloride on carotid chemosensory fibers in pentobarbital-anesthetized cats that were paralyzed and artificially ventilated. Responses of carotid chemoreceptor afferents to graded doses of cobalt given by intra-arterial injections (0.08-2.10 mumols) were measured at constant blood gases. Responses of the same chemoreceptor afferents to hypoxia, before and after a saturation dose of cobalt, were measured. In two experiments carotid body tissue PO2 was also simultaneously measured. The chemosensory fibers showed prolonged excitation after a brief period of inhibition subsequent to cobalt administration. The stimulatory effect showed a dose-dependent saturation response. Cobalt augmented rather than blocked carotid chemoreceptor response to hypoxia. The effect of cobalt was not mediated by tissue PO2. These results are consistent with the hypothesis that cobalt stimulates the O2-sensing mechanism, although a direct effect of cobalt on the excitability of the chemosensory terminal remains a possibility.
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Details
- Title
- Cobalt stimulates carotid body chemoreceptors
- Creators
- C. Di Giulio - University of PennsylvaniaW. X. Huang - Department of Physiology, University of Pennsylvania School of Medicine, PhiladelphiaS. Lahiri - Department of Physiology, University of Pennsylvania School of Medicine, PhiladelphiaA. Mokashi - Department of Physiology, University of Pennsylvania School of Medicine, PhiladelphiaD. G. Buerk - University of Pennsylvania
- Publication Details
- Journal of applied physiology (1985), v 68(5), pp 1844-1849
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1990DG20500013
- Scopus ID
- 2-s2.0-0025302355
- Other Identifier
- 991019184197504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physiology
- Sport Sciences