Journal article
Cobamide remodeling
Vitamins and hormones, v 119, pp 43-63
2022
PMID: 35337629
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cobamides are a family of structurally-diverse cofactors which includes vitamin B
and over a dozen natural analogs. Within the nucleotide loop structure, cobamide analogs have variable lower ligands that fall into three categories: benzimidazoles, purines, and phenols. The range of cobamide analogs that can be utilized by an organism is dependent on the specificity of its cobamide-dependent enzymes, and most bacteria are able to utilize multiple analogs but not all. Some bacteria have pathways for cobamide remodeling, a process in which imported cobamides are converted into compatible analogs. Here we discuss cobamide analog diversity and three pathways for cobamide remodeling, mediated by amidohydrolase CbiZ, phosphodiesterase CbiR, and some homologs of cobamide synthase CobS. Remodeling proteins exhibit varying degrees of specificity for cobamide substrates, reflecting different strategies to ensure that imported cobamides can be utilized.
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Details
- Title
- Cobamide remodeling
- Creators
- Amy T Ma - Drexel UniversityDaniel S Kantner - Drexel UniversityJoris Beld - Drexel University
- Publication Details
- Vitamins and hormones, v 119, pp 43-63
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000893219700003
- Scopus ID
- 2-s2.0-85125643592
- Other Identifier
- 991019173908104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism